Bakterielle Translokation beim kritisch kranken Patienten mit aneurysmatischer Subarachnoidalblutung

Flachs Nóbrega, Silvia

dc.contributor.advisor	Schäper, Jörn PD Dr.
dc.contributor.author	Flachs Nóbrega, Silvia
dc.date.accessioned	2023-02-16T14:29:33Z
dc.date.available	2023-03-02T00:50:10Z
dc.date.issued	2023-02-16
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14516
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9731
dc.format.extent	72	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Bakterielle Translokation beim kritisch kranken Patienten mit aneurysmatischer Subarachnoidalblutung	de
dc.type	doctoralThesis	de
dc.title.translated	Bacterial translocation in the critically ill patient with aneurysmal subarachnoid hemorrhage	de
dc.contributor.referee	Schäper, Jörn PD Dr.
dc.date.examination	2023-02-22	de
dc.description.abstracteng	Sepsis is the most common reason for the death of critically ill patients. The pathogenesis of sepsis is therefore of central importance in order to find therapeutic approaches for this common clinical picture. The strictest possible definition of the patient group to be examined and the point in time at which organ dysfunction or organ failure occurs in the course of intensive care medicine play an important role in order to be able to draw conclusions about the causality of influencing factors. A disrupted epithelial intestinal barrier with consecutive bacterial translocation and endotoxemia is ascribed a central role in the pathogenesis of septic multi-organ failure. Despite a large number of experimental and clinical studies, the data on the causal relationship between epithelial barrier disruption, bacterial translocation and the prognostic value for the survival of a critically ill patient in the literature to date are scarce and inhomogeneous. This study was carried out to reassess the processes in the intestinal epithelium of critically ill patients using modern analysis methods and to examine a translocation, i.e. a transfer of bacteria or their components from the intestinal lumen into the systemic circulation as a predictor for organ failure. For this purpose, a group of patients was selected who had suffered a spontaneous aneurysmal subarachnoid hemorrhage (SAH).	de
dc.contributor.coReferee	Mielke, Dorothee Prof. Dr.
dc.subject.eng	sepsis	de
dc.subject.eng	bacterial translocation	de
dc.subject.eng	epithelial barrier disruption	de
dc.subject.eng	spontaneous aneurysmal subarachnoid hemorrhage	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14516-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Anästhesiologie / Intensivmedizin / Notfallmedizin / Analgesie - Allgemein- und Gesamtdarstellungen (PPN619875917)	de
dc.description.embargoed	2023-03-02	de
dc.identifier.ppn	1836921454
dc.creator.birthname	Schultze	de
dc.notes.confirmationsent	Confirmation sent 2023-02-16T14:45:01	de

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Human- und Zahnmedizin [2873]

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