Evaluation von Messinstrumenten bei der allergologischen Diagnostik vor und während einer spezifischen Immuntherapie mit Hymenopterengiftextrakt

Lorbeer, Lisa

dc.contributor.advisor	Buhl, Timo Prof. Dr.
dc.contributor.author	Lorbeer, Lisa
dc.date.accessioned	2023-03-07T09:10:48Z
dc.date.available	2023-03-14T00:50:10Z
dc.date.issued	2023-03-07
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14559
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9759
dc.format.extent	85	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Evaluation von Messinstrumenten bei der allergologischen Diagnostik vor und während einer spezifischen Immuntherapie mit Hymenopterengiftextrakt	de
dc.type	doctoralThesis	de
dc.title.translated	Evaluation of measuring instruments in allergological diagnostics before and during specific immunotherapy with hymenopteran venom extract	de
dc.contributor.referee	Lex, Christiane Prof. Dr.
dc.date.examination	2023-03-07	de
dc.description.abstracteng	Allergies against Hymenoptera venoms are one of the most common causes of severe anaphylactic reactions, besides food and drug allergies. The diagnosis of suspected Hymenoptera venom allergy consists of patient history, serological parameters and skin tests. The risk for recurrent anaphylaxis in case of a new sting event cannot be determined by any biomarker. Up to now, parameters such as comorbidities, medication intake, and the initial degree of anaphylaxis have been known to provide a rough estimate of the likelihood of a recurrence of severe anaphylaxis. For risk minimization, there is the option of specific immunotherapy (SIT). Especially during therapy, the effectiveness is undisputed. In a retrospective study, we analyzed the serological parameters and the results of intracutaneous skin testing before and during SIT. At the beginning of SIT, elevated gift-specific IgE levels are typical. In our collective, this decreased significantly over years. In contrast, there was an increase in gift-specific IgG and IgG4 levels, which increased significantly during the first 48 months of SIT. Overall, in the time course of SIT in our collective, including all venom concentrations, no clear tendency for area reduction of urticae in the intracutaneous tests could be demonstrated. Nontheless, a revised guideline for diagnosis and therapy in hymenopteran venom allergic patients is needed. Despite all the evidence from the current literature, the establishment of a guideline will continue to be difficult in the future.	de
dc.contributor.coReferee	Dressel, Ralf Prof. Dr.
dc.subject.eng	intracutaneous test	de
dc.subject.eng	allergy	de
dc.subject.eng	insect venom allergy	de
dc.subject.eng	specific IgE	de
dc.subject.eng	specific immunotherapy	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14559-5
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174)	de
dc.description.embargoed	2023-03-14	de
dc.identifier.ppn	1838504133
dc.notes.confirmationsent	Confirmation sent 2023-03-07T09:15:01	de

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Human- und Zahnmedizin [2871]

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