New Synthetic Analogues for Biological Fe/S Clusters

von Lanxia Hu
Dissertation
Datum der mündl. Prüfung:2023-02-21
Erschienen:2023-03-20
Betreuer:Prof. Dr. Franc Meyer
Gutachter:Prof. Dr. Inke Siewert
Gutachter:Prof. Dr. Lisa Vondung
Gutachter:Prof. Dr. Anna Krawczuk
Gutachter:Dr. Michael John
Gutachter:Dr. Holm Frauendorf
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-9794

 

 

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Zusammenfassung

Englisch

Iron-sulfur (Fe/S) clusters are omnipresent and are essential components in virtually all life forms due to their versatile structures and functions. Biological systems extensively employ Fe/S clusters, especially with rhombic [2Fe-2S] and cubane-type [4Fe-4S] cores for electron transfer, catalysis, etc. Studies on synthetic Fe/S complexes have provided deeper insight into their structures and functions. By comparison, asymmetrical Fe/S clusters are not well investigated. This thesis mainly focuses on establishing novel synthetic analogues for biological asymmetrical [2Fe-2S] and [4Fe-4S] clusters. A series novel of [2Fe-2S] and [4Fe-4S] clusters were synthesized and fully characterized, and their redox properties were investigated. The detailed research of these clusters deepened our understanding of asymmetrical Fe/S clusters.
Keywords: [2Fe-2S] clusters, [4Fe-4S] clusters, asymmetrical Fe/S clusters; [4Fe-4S] clusters; asymmetrical Fe/S clusters
 
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