Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik

Dietmann, Anne-Sophie

dc.contributor.advisor	Metz, Imke PD Dr.
dc.contributor.author	Dietmann, Anne-Sophie
dc.date.accessioned	2023-04-18T10:06:00Z
dc.date.available	2023-04-25T00:50:10Z
dc.date.issued	2023-04-18
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14624
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9843
dc.format.extent	71	de
dc.language.iso	deu	de
dc.subject.ddc	610	de
dc.title	Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik	de
dc.type	doctoralThesis	de
dc.title.translated	Neurofilament light chains in serum as biomarkers of axonal damage in early MS lesions: a histological-serological correlative study	de
dc.contributor.referee	Metz, Imke PD Dr.
dc.date.examination	2023-04-18	de
dc.description.abstracteng	Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL) are considered a biomarker for this damage. We aimed to investigate the relationship between sNfL and the axonal damage in early MS lesions in a special cohort of biopsied patients. sNfL from 106 biopsied patients with 26 follow-up samples were analyzed using single-molecule array (SiMoA) technology. Findings were correlated with clinical parameters and histological findings of acute axonal damage (APP-positive spheroids) and axonal loss in different lesion stages. A median of 59 pg/ml sNfL was found (range 8-3101 pg/ml). sNfL levels correlated with APP-positive spheroids in early active demyelinating lesions that represent the earliest lesion stages (p < 0.01). A significant negative correlation between sNfL levels in follow-up blood samples and axonal density in normal-appearing white matter was also observed (p = 0.02). sNfL levels correlated with the Expanded Disability Status Score at biopsy (p < 0.01, r = 0.49) and at last clinical follow-up (p < 0.01, r = 0.66). In conclusion, sNfL likely represent a compound measure of recent and ongoing neuroaxonal damage. We found that sNfL in biopsied MS patients correlate with acute axonal damage in the earliest MS lesion stages. Determination of sNfL levels thus allows insight into brain pathology and underlines the relevance of relapse-associated lesional pathology. Axonal loss in normal-appearing white matter contributes to sNfL levels independent of relapses. Since sNfL levels correlate with clinical disability, they may predict the future disability of patients and help with individual treatment decisions.	de
dc.contributor.coReferee	Huppke, Peter Prof. Dr.
dc.subject.ger	Multiple Sklerose	de
dc.subject.ger	Neurofilament Leichtketten	de
dc.subject.ger	axonaler Schaden	de
dc.subject.eng	early multiple sclerosis	de
dc.subject.eng	axonal damage	de
dc.subject.eng	Neurofilament light chains	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14624-2
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.subject.gokfull	Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)	de
dc.description.embargoed	2023-04-25	de
dc.identifier.ppn	1843240904
dc.creator.birthname	Beutler	de
dc.notes.confirmationsent	Confirmation sent 2023-04-18T10:15:01	de

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Human- und Zahnmedizin [2872]

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