Gene Expression Analysis in Models of Cognitive Diseases

Cortes Silva, Jonathan Alexis

dc.contributor.advisor	Fischer, André Prof. Dr.
dc.contributor.author	Cortes Silva, Jonathan Alexis
dc.date.accessioned	2023-04-18T14:09:49Z
dc.date.available	2023-04-25T00:50:10Z
dc.date.issued	2023-04-18
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14629
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-9840
dc.description.sponsorship	Deutscher Akademischer Austauschdienst (DAAD)	de
dc.format.extent	XXX Seiten	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Gene Expression Analysis in Models of Cognitive Diseases	de
dc.type	cumulativeThesis	de
dc.contributor.referee	Wollnik, Bernd Prof. Dr.
dc.date.examination	2023-04-06	de
dc.description.abstracteng	Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to the high prevalence of these disorders (Saarni et al., 2007). Despite a wealth of knowledge regarding the behavioral manifestations of these disorders, understanding the underlying cellular mechanisms remains a major challenge. Furthermore, research has revealed that these diseases are complex and heterogeneous (Wu & Yang, 2022; Young et al., 2018), with individuals who share similar diagnoses often exhibiting diverse responses to treatments and distinct cellular processes. Consequently, there is a pressing need to further investigate the cellular mechanisms that underlie neuropsychiatric and neurodegenerative diseases to develop more effective treatments for affected individuals. In this context, this cumulative thesis developed an analysis of genetic expression in three models of cognitive diseases. An animal model for Major Depression (MD), the APP/PS1-21 as a model for the study of Alzheimer’s disease, and two experiments in hIPSC and BENOS for the study of genetic expression in Floating Harbor Syndrome (FHS).	de
dc.contributor.coReferee	Goya-Maldonado, Roberto PD Dr.
dc.contributor.thirdReferee	Outeiro, Tiago Fleming Prof. Dr.
dc.contributor.thirdReferee	Wirths, Oliver Prof. Dr.
dc.contributor.thirdReferee	Werner, Hauke Dr.
dc.subject.eng	Major Depression	de
dc.subject.eng	Gene expression	de
dc.subject.eng	Cognition	de
dc.subject.eng	Neurodegeneration	de
dc.subject.eng	Neuropsychiatric	de
dc.subject.eng	Congenital	de
dc.subject.eng	Diseases	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14629-4
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.description.embargoed	2023-04-25	de
dc.identifier.ppn	1843241005
dc.notes.confirmationsent	Confirmation sent 2023-04-18T14:15:01	de

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Format:: PDF
Beschreibung:: Cumulative thesis

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Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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