Pathophysiological effects of Beta-Synuclein mutants P123H and V70M

by Sofia Marina Guerin Darvas
Doctoral thesis
Date of Examination:2023-04-12
Date of issue:2023-07-24
Advisor:Dr. Sebastian Kügler
Referee:Prof. Dr. Thomas Dresbach
Referee:Dr. Manuela Schmidt
Referee:Dr. Hauke Werner
Referee:Dr. Sonja Wojcik
Referee:Prof. Dr. Tiago Fleming Outeiro
Persistent Address: http://dx.doi.org/10.53846/goediss-10008

 

 

Files in this item

Name:Thesis_Sofia Guerin_Corrected version_Affidavit.pdf
Size:41.6Mb
Format:PDF
Description:Corrected thesis without CV, with Affidavit.

The following license files are associated with this item:

Abstract

English

Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic case of the disease. Previous work done in overexpression studies have shown that these two mutants might exert their neurotoxicity through different cellular pathways: V70M affecting mitochondrial fitness and P123H impairing spontaneous neuronal activity. The objective of this thesis was to gain more insight into how these proteins exert such different effects. Results show that while these proteins interact with the same affinity with biologically relevant membranes, their neurotoxicity might relay on their different aggregation propensities.
Keywords: Dementia, synuclein; Dementia, synuclein
 
Statistik