Der Einfluss von Δ9-Tetrahydrocannabinol und Cannabidiol auf die Pathologie des Morbus Alzheimer im Tg4-42hom-Mausmodell

by Malte Maßmann
Doctoral thesis
Date of Examination:2023-10-12
Date of issue:2023-09-29
Advisor:PD Dr. Yvonne Bouter
Referee:PD Dr. Yvonne Bouter
Referee:Prof. Dr. Thomas Dresbach
Persistent Address: http://dx.doi.org/10.53846/goediss-10078

 

 

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Abstract

English

This thesis evaluates the histopathological effects of a long-term application of Cannabidiol and delta-Tetrahydrocannabiol in a mouse model of the sporadic Alzheimer`s disease in a preventive and therapeutic approach regarding histopathological markers of neuro-inflammation, neurogenesis, hippocampal neurodegeneration and expression of the CB1-Receptor. Whilst beneficial effects can be shown in the preventive approach of treatment, such can not be ascertained for the therapeutic approach of treatment.
Keywords: Alzheimer`s; Cannabidiol; THC; Tg4-42
 
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