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Zerebrale Perfusion in der Akutphase nach aneurysmatischer Subarachnoidalblutung - Einsatz der CT-Perfusion für die Erfassung der frühen Hirnschädigung und der verzögerten zerebralen Ischämie

dc.contributor.advisorRohde, Veit Prof. Dr.
dc.contributor.authorMalinova, Vesna PD Dr.
dc.date.accessioned2023-10-24T07:45:09Z
dc.date.available2023-10-25T00:50:30Z
dc.date.issued2023-10-24
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/14931
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-10157
dc.format.extent47de
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610de
dc.titleZerebrale Perfusion in der Akutphase nach aneurysmatischer Subarachnoidalblutung - Einsatz der CT-Perfusion für die Erfassung der frühen Hirnschädigung und der verzögerten zerebralen Ischämiede
dc.typehabilitationde
dc.contributor.refereeanonym
dc.date.examination2020-07-20de
dc.description.abstractengAneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease associated with high morbidity and mortality due to early brain injury (EBI) and delayed complications like delayed cerebral ischemia (DCI). Imaging plays an important role for early detection of DCI to allow timely initiation of therapeutic measures and to prevent the occurrence of infarctions with permanent neurological deficits. While most previous publications focus on DCI, the role of EBI in the pathophysiology of DCI has been increasingly recognized in the past years. In this cumulative habilitation, the diagnostic value of computed tomography perfusion (CTP) for early prediction of DCI and for evaluation of EBI severity was evaluated and discussed. Cutoff-values for all CTP parameters were defined after performing quantitative analyses. Time to drain (TTD) was the CTP parameter with the highest discriminatory power for early prediction of DCI. Additionally, increased tissue permeability measured by CTP in the early phase after aSAH was associated with higher incidence of DCI. An elaborated imaging protocol including CTP allows an early prediction of DCI, which can be useful for guiding treatment decisions during the acute management of patients with aSAH at the intensive care unit.de
dc.contributor.coRefereeanonym
dc.subject.enganeurysmal subarachnoid hemorrhagede
dc.subject.engcomputed tomography perfusionde
dc.subject.engdelayed cerebral ischemiade
dc.identifier.urnurn:nbn:de:gbv:7-ediss-14931-3
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullChirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968)de
dc.description.embargoed2023-10-25de
dc.identifier.ppn1869813340
dc.notes.confirmationsentConfirmation sent 2023-10-24T08:15:01de


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