Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii

Platte, Christian

dc.contributor.advisor	Groß, Uwe Prof. Dr.
dc.contributor.author	Platte, Christian
dc.date.accessioned	2023-11-09T17:40:40Z
dc.date.available	2023-11-22T00:50:10Z
dc.date.issued	2023-11-09
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14966
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-10155
dc.format.extent	93	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii	de
dc.type	doctoralThesis	de
dc.title.translated	Inhibitory effects of 1-hydroxyquinolones on Toxoplasma gondii	de
dc.contributor.referee	Groß, Uwe Prof. Dr.
dc.date.examination	2023-11-14	de
dc.description.abstracteng	Within the mitochondria of Toxoplasma gondii, 1-hydroxyquinolones were identified as affine inhibitors of the alternative NADH-dehydrogenase at the first complex of the respiratory chain. Another target structure of the compound was confirmed to be the dihydroorotate-dehydrogenase, an enzyme in pyrimidine biosynthesis. The mode of action of the substances was also examined by the use of two deletion-mutants and the length of the alkyl side chain of the 1-hydroxyquinolones was identified as a structurally important and functional aspect. As a result, hydroxyquinolones exerted a parasitostatic effect on Toxoplasma gondii in long-term experiments and the parasite almost stopped its dividing activity. Furthermore, under the influence of hydroxyquinolones, a significant decrease in ATP content and a disruption of the mitochondrial membrane potential (ΔΨm) were detected in Toxoplasma gondii, which illustrated the influence of the compounds on the metabolism of the parasite.	de
dc.contributor.coReferee	Hahn, Alexander PD Dr.
dc.contributor.thirdReferee	Dressel, Ralf Prof. Dr.
dc.subject.ger	Toxoplasma gondii	de
dc.subject.ger	Atmungskette	de
dc.subject.ger	Hydroxychinolon	de
dc.subject.ger	1-Hydroxychinolon	de
dc.subject.ger	Wachstumshemmung	de
dc.subject.ger	ATP-Gehalt	de
dc.subject.ger	Membranpotential	de
dc.subject.eng	toxoplasma gondii	de
dc.subject.eng	hydroxyquinolones	de
dc.subject.eng	respiratory chain	de
dc.subject.eng	growth inhibition	de
dc.subject.eng	Inhibitory effect	de
dc.subject.eng	mitochondrial membrane potential	de
dc.subject.eng	atp content	de
dc.subject.eng	parasite	de
dc.subject.eng	1-hydroxyquinolones	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-14966-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizinische Mikrobiologie / Medizinische Virologie / Medizinische Mykologie / Infektionskrankheiten / Hygiene / Impfung / Parasitologie / Tropenmedizin - Allgemein- und Gesamtdarstellungen (PPN619875356)	de
dc.description.embargoed	2023-11-22	de
dc.identifier.ppn	1870497309
dc.notes.confirmationsent	Confirmation sent 2023-11-09T19:45:01	de

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