Sustainable Ruthenium- and Rhodium-Catalyzed C−H Activations with Photochemistry and Electrochemistry

von Agnese Zangarelli
Dissertation
Datum der mündl. Prüfung:2024-02-29
Erschienen:2024-03-18
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Konrad Koszinowski
Gutachter:Prof. Dr. Franc Meyer
Gutachter:Prof. Dr. Dr. Lutz Tietze
Gutachter:Dr. Holm Frauendorf
Gutachter:Dr. Daniel Janßen-Müller
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-10400

 

 

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Zusammenfassung

Englisch

Cross-coupling chemistry stands out as a fundamental tool in synthetic organic chemistry for forging C‒C and C‒Het bonds. However, the necessity for substrate prefunctionalization imposes significant sustainability challenges on these transformations. In contrast, advancements in transition metal-catalyzed direct functionalization of ubiquitous C‒H bonds present a more sustainable avenue for constructing complex molecular structures. Despite the pivotal contributions of C–H activation, also driven by key principles like atom- and step-economy, this approach has inherent limitations. To overcome these, innovative mechanistic pathways integrating renewable energy sources in electrocatalysis and photocatalysis are pursued to address issues related to hazardous chemical oxidants and harsh reaction conditions. Additionally, with the aim of synthetic utility and applicability in drug discovery and medicinal chemistry, late-stage C–H functionalization can be implemented with the promise for simplifying reaction pathways and diversifying product outputs. These themes constitute the central investigative focus of this thesis.
Keywords: Catalysis; C–H Activation; C–H Functionalization; Sustainability; Photochemistry; Electrochemistry; Late-Stage Functionalization
 
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