Show simple item record

Knöcherne Veränderungen an Schädelcalotten einer rezenten Population von Körperspendern aus dem Zentum Anatomie der Universitätsmedizin Göttingen: Ein Beitrag zur Paläopathologie

dc.contributor.advisorSchultz, Michael Prof. Dr. Dr.
dc.contributor.authorFreundt, Martin
dc.titleKnöcherne Veränderungen an Schädelcalotten einer rezenten Population von Körperspendern aus dem Zentum Anatomie der Universitätsmedizin Göttingen: Ein Beitrag zur Paläopathologiede
dc.title.translatedBone changes in cranial vaults of a contemporary population of body donors from the Anatomy Center of the University Medical Center Göttingen: A contribution to
dc.contributor.refereeSchultz, Michael Prof. Dr. Dr.
dc.description.abstractengMany works in the field of geriatrics and gerontology have focused on the anatomical, physiological, and biochemical changes in the aging organism and their mutual influence. However, in paleopathological research, aside from degenerative changes, this topic represents a gap. Distinguishing between physiological, purely age-related, non-pathological changes and pathological changes is often difficult due to their mutual influence—especially in archaeological bone finds, where this distinction is often complicated by postmortem changes. Against this background, the question arose as to whether such age-related physiological and pathological changes are present in a contemporary population and how they manifest. Furthermore, the question arose of whether it is possible to differentiate between physiological age-related changes and pathological changes based on morphological findings, and whether these changes show a dependence on age and sex. Also of interest was the extent to which these changes mutually influence their morphological appearance. In order to contribute to anthropological-paleopathological assessment, the pathomechanisms and diseases underlying bone changes were made plausible. For this purpose, 616 skullcaps from body donations that died between 1985 and 2005 were examined for bony changes. In order to do justice to the entire extent of bone changes on the skull roof, the results of macroscopic, microscopic, and radiological findings were presented and detailed in selected case examples. A variety of images were used in the work to facilitate the comparison of findings on archaeological bone finds. Regarding age, statistical relevance could not be demonstrated due to the mostly small sample size of affected individuals and a generally insufficient representation of younger individuals. In most cases, a balanced distribution of sexes could be demonstrated. An exception was found in the frequency of enlarged impressions of meningeal vessels and the associated neoplasia in the marginal area of meningeal vessels and traces of perisinuous processes. In these cases, women were statistically significantly more affected by these changes than men. The bone changes were also discussed against the background of metabolic, structural, and immunological aging changes to demonstrate their diverse interplay mechanisms. In summary, it must be said that in the discussion of bone changes, there often appears to be a blurry boundary between the physiological and the pathological. It was shown that bone changes such as substance loss, neoplasia, and traces of hypervascularization, which are primarily associated with pathological processes, can often be strongly influenced by the effects of physiological aging changes. Consequently, it is worth discussing whether these changes could be age-related bone modulations. This is a matter that requires further study for subsequent
dc.contributor.coRefereeGrellner, Wolfgang Prof. Dr.
dc.subject.engSkull capde
dc.subject.engCranial vaultde
dc.subject.engSkull roofde
dc.subject.engCranial domede
dc.subject.engArchaeological bone findde
dc.subject.engAnthropological-paleopathological assessmentde
dc.subject.engAge-related bone modulationsde
dc.subject.engBone changesde
dc.subject.engBony substance lossde
dc.subject.engBony neoplasiade
dc.subject.engBony traces of hypervascularizationde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.notes.confirmationsentConfirmation sent 2024-05-15T11:45:01de

Files in this item


This item appears in the following Collection(s)

Show simple item record