Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle

by Yunxiao Zhang
Doctoral thesis
Date of Examination:2024-04-19
Date of issue:2024-05-28
Advisor:Prof. Dr Xiaoming Fu
Referee:Prof. Dr Xiaoming Fu
Referee:Dr. Yong Wang
Persistent Address: http://dx.doi.org/10.53846/goediss-10512

 

 

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Abstract

English

This dissertation investigates the biomechanics of the left ventricle across multiple geometric levels toward personalized cardiac modeling with engineered heart muscle. Firstly, a physics-based model for the EDPVR and ESPVR of the LV represented by a thick-wall sphere with interpretable parameters is proposed, and the PV relationships of the LV are investigated. Then, the influence of fiber architecture on LV pump function is investigated using an idealized LV model of a truncated ellipsoid. Finally, a workflow for personalized cardiac modeling is developed, which benefits public health by contributing to new treatment methods for heart disease. This work deepens our understanding of cardiac mechanics. By combining computer science, mathematics, physics and medicine, a digital heart twin can be created for specific patients.
Keywords: Left Ventricle; Biomechanics; Heart Modeling; Numerical Modeling; Finite Element Method
 
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