Palladium- and Ruthenium-Catalyzed C(sp2)–H and C(sp3)–H Arylations

by Darko Santrač
Doctoral thesis
Date of Examination:2023-06-07
Date of issue:2024-06-05
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Konrad Koszinowski
Referee:Dr. Michael John
Referee:Prof. Dr. Anna Krawczuk
Referee:Prof. Dr. Nadja Simeth
Referee:Dr. Holm Frauendorf
Persistent Address: http://dx.doi.org/10.53846/goediss-10524

 

 

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Abstract

English

Catalysis is arguably the most impactful area of chemistry for society today, driven by the urgent need for highly efficient and environmentally benign reactions. C−H activation, which allows for the direct introduction of functional groups into substrate molecules without prior functionalization, represents a significant advancement over traditional cross-coupling reactions. This thesis focuses on three main areas: the perfluoroarylation of benzene, the arylation of benzoxazoles using in situ generated tosylates, and, finally, the arylation of C(sp2)−H and C(sp3)−H bonds by chelation assistance. In the last project, a novel triazole directing group (TAM) has been employed, demonstrating its effectiveness in facilitating these transformations.
Keywords: Catalysis; C–H Activation; C–H Functionalization; Ruthenium catalysis; Palladium catalysis; Directing group
 
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