Neuronal glucose metabolism in amyotrophic lateral sclerosis

Dannenberg, Jana Sophia

dc.contributor.advisor	Koch, Jan C. PD Dr.
dc.contributor.author	Dannenberg, Jana Sophia
dc.date.accessioned	2024-06-28T14:55:02Z
dc.date.available	2024-07-25T00:50:08Z
dc.date.issued	2024-06-28
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15335
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-10548
dc.format.extent	102	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Neuronal glucose metabolism in amyotrophic lateral sclerosis	de
dc.type	doctoralThesis	de
dc.contributor.referee	Koch, Jan C. PD Dr.
dc.date.examination	2024-06-27	de
dc.description.abstracteng	ALS is a rapidly progressing neurodegenerative disease characterized by motor neuron death ultimately leading to paralysis and respiratory failure. While a great deal of progress has been made deciphering the underlying pathogenic pathways, no curative therapy is available today. Over the last few decades, alterations in energy homeostasis and glucose metabolism have emerged as common features across many different forms of ALS. Disturbed energy homeostasis and a general hypermetabolism are observed in ALS patients even before motor symptoms begin, suggesting it to be an early and possibly causative factor in disease progression. A regional glucose hypometabolism in ALS-associated brain regions has been shown by various studies, but data illuminating the molecular level is still scarce. This study examines the expression and activity of key glucose metabolism enzymes both in-vitro in a TDP-43 (wildtype and M337V mutation) overexpression cortical neuron cell culture as well as in-vivo analyzing serum and CSF of ALS patients compared to controls. The observed decrease in enzyme activity in-vitro and decreased enzyme expression in-vivo support the hypothesis of glucose hypometabolism and strengthen the role of energy metabolism playing a part in future ALS diagnostics and therapy.	de
dc.contributor.coReferee	Thumm, Michael Prof. Dr.
dc.subject.eng	ALS	de
dc.subject.eng	Energy metabolism	de
dc.subject.eng	Glucose metabolism	de
dc.subject.eng	Glycolysis	de
dc.subject.eng	CSF	de
dc.subject.eng	Serum	de
dc.subject.eng	Enzyme expression	de
dc.subject.eng	Enzyme activity	de
dc.subject.eng	AMPK	de
dc.subject.eng	Western blot	de
dc.subject.eng	TDP-43	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15335-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2024-07-25	de
dc.identifier.ppn	1892742683
dc.notes.confirmationsent	Confirmation sent 2024-06-28T15:15:01	de

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