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Identifikation und Charakterisierung von Typ-II-Neuroblasten im Embryo des Mehlkäfers Tribolium castaneum

dc.contributor.advisorViebahn, Christoph Prof. Dr.
dc.contributor.authorRethemeier, Simon
dc.date.accessioned2024-08-16T10:41:02Z
dc.date.available2024-09-24T00:50:09Z
dc.date.issued2024-08-16
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/15427
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-10679
dc.description.sponsorshipJacob-Henle-Programm der Universitätsmedizin Göttingende
dc.format.extent65de
dc.language.isodeude
dc.subject.ddc610de
dc.titleIdentifikation und Charakterisierung von Typ-II-Neuroblasten im Embryo des Mehlkäfers Tribolium castaneumde
dc.typedoctoralThesisde
dc.title.translatedIdentification and characterisation of type II neuroblasts in the embryo of the red flour beetle Tribolium castaneumde
dc.contributor.refereeViebahn, Christoph Prof. Dr.
dc.date.examination2024-08-28de
dc.description.abstractengEvolution has created a wide range of morphological diversity in insect brains, while the basic structure is conserved. Little is known about the mechanisms that lead to this evolutionary diversification of similar structures. The central complex, one of these neuropiles, shows evolutionary heterochrony: While the hemimetabolious grasshopper Schistocerca gregaria builds up this whole structure during the embryonic period, the highly derived holometabolous fruit fly Drosophila melanogaster develops it mainly in the late larval and pupal stages. Neurogenesis in insects is carried out by neuroblasts. Most of the insect nervous system is build up by type I neuroblasts but for central complex development in Drosophila and Schistocerca also type II neuroblasts have been discovered. Those have the ability to produce more progeny by generating intermediate progenitor cells. Regarding to the central complex development, the red flour beetle Tribolium castaneum shows an intermediate position by building up an immature but already functional version of this neuropil in the late embryo. Using mRNA in situ hybridisation and antibody staining on transgenic lines that mark distinct genes, this work identified actively proliferating cell lines produced by type II neuroblasts in the Tribolium embryo that take part in the embryonic central complex genesis. A high degree of conservation could be shown, especially regarding their dorsomedial position in the embryonic head and their characteristic gene expression pattern, which appears homologous to the situation in Drosophila. However, the unexpected finding that Tribolium generates nine type II neuroblasts, while only eight could be found in Drosophila and Schistocerca, combined with the fact that Tribolium embryonic type II lines could be characterised as containing significantly more cells than those in Drosophila leads to the conclusion that embryonic type II neuroblasts seem to be a factor for the relatively earlier central complex development in Tribolium. Regarding this, type II neuroblasts appear also as an interesting model for further studies on heterochrony during insect brain development.de
dc.contributor.coRefereeBucher, Gregor Prof. Dr.
dc.subject.gerCentralcomplexde
dc.subject.gerTyp-I-Neuroblastde
dc.subject.gerTyp-II-Neuroblastde
dc.subject.gerHeterochroniede
dc.subject.gerNeurogenesede
dc.subject.gerInsektde
dc.subject.gerNervensystemde
dc.subject.gerEvolutionde
dc.subject.engTribolium castaneumde
dc.subject.engTriboliumde
dc.subject.engtype I neuroblastde
dc.subject.engtype II neuroblastde
dc.subject.engcentral complexde
dc.subject.engpointedde
dc.subject.engfezde
dc.subject.engneuroblastde
dc.subject.engheterochronyde
dc.subject.engneurogenesisde
dc.subject.engembryode
dc.subject.enginsectde
dc.subject.engnervous systemde
dc.subject.engevolutionde
dc.subject.engintermediate progenitor cellde
dc.subject.engganglion mother cellde
dc.subject.engdeadpande
dc.subject.engasensede
dc.identifier.urnurn:nbn:de:gbv:7-ediss-15427-4
dc.date.embargoed10000-01-01
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.description.embargoed2024-09-24de
dc.description.embargoed10000-01-01
dc.identifier.ppn1899060588
dc.notes.confirmationsentConfirmation sent 2024-08-16T10:45:01de
dc.description.embargotextgerDiese Dateien sind bis zum Abschluß der Staatsexamensprüfung gesperrt
dc.description.embargotextengThese files are not accessible until the state exam has been completed


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