Vergleich klinischer und epidemiologischer Parameter der primären Gliomatosis cerebri und primär multifokaler hochgradiger Gliome im Kindes- und Jugendalter

Tacke, Anna

dc.contributor.advisor	Kramm, Christof Prof. Dr.
dc.contributor.author	Tacke, Anna
dc.date.accessioned	2024-08-26T08:37:25Z
dc.date.available	2024-09-23T00:50:10Z
dc.date.issued	2024-08-26
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15447
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-10699
dc.format.extent	VI, 69	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Vergleich klinischer und epidemiologischer Parameter der primären Gliomatosis cerebri und primär multifokaler hochgradiger Gliome im Kindes- und Jugendalter	de
dc.type	doctoralThesis	de
dc.title.translated	Comparison of clinical and epidemiological parameters of primary Gliomatosis cerebri and primary multifocal high-grade gliomas in childhood and adolescence	de
dc.contributor.referee	Kramm, Christof Prof. Dr.
dc.date.examination	2024-09-03	de
dc.description.abstracteng	To date no differentiation is being made between varying growth phenotypes of pediatric high-grade gliomas (pHGG). This thesis compares primary pediatric Gliomatosis cerebri (GC) and primary multifocal/multicentric (PMF) pediatric high-grade gliomas as rare growth phenotypes in regard to epidemiological, clinical and prognostic parameters as opposed to pHGG that primarily grow as solitary tumor nodules. For this purpose, 51 patients with primary pediatric GC, 37 patients with PMF pediatric high-grade gliomas and a total of 997 control patients, divided into specific, adapted comparison cohorts, were identified from the database of the HIT-HGG study group of the Society for Pediatric Oncology and Hematology in Germany, Austria and German-speaking Switzerland (GPOH). In regard to epidemiological and clinical parameters, primary pediatric GC and PMF pediatric high-grade gliomas differed significantly in terms of histological diagnoses, extent of tumor resection and radiation dose. An interesting and potentially clinically relevant observation, although not yet statistically significant, was the presence of tumor predisposition syndromes, which were present in 20% of PMF pediatric high-grade gliomas, but in only 3% of the primary pediatric GC cases. A comparison of the survival data shows that both primary pediatric GC and PMF pediatric high-grade gliomas have an even worse prognosis than the usual growth phenotypes of pHGG, which already have a dismal prognosis. Only diffuse intrinsic pontine gliomas/diffuse midline gliomas have a similarly poor prognosis. The current WHO classification of tumors of the central nervous system does not do justice to these relevant differences in survival.	de
dc.contributor.coReferee	Bock, Hans Christoph PD Dr.
dc.subject.ger	Gliomatosis cerebri	de
dc.subject.ger	multifokal	de
dc.subject.ger	pädiatrisches hochgradiges Gliom	de
dc.subject.ger	pHGG	de
dc.subject.eng	pediatric high-grade glioma	de
dc.subject.eng	Gliomatosis cerebri	de
dc.subject.eng	multifocal	de
dc.subject.eng	pHGG	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15447-5
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Pädiatrie / Neonatologie / Kinderchirurgie - Allgemein- und Gesamtdarstellungen (PPN619876093)	de
dc.description.embargoed	2024-09-23	de
dc.identifier.ppn	1899863680
dc.notes.confirmationsent	Confirmation sent 2024-08-26T08:45:01	de

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