| dc.contributor.advisor | Stadelmann-Nessler, Christine Prof. Dr. | |
| dc.contributor.author | Aber, Mogadassa | |
| dc.date.accessioned | 2024-08-26T11:16:09Z | |
| dc.date.available | 2024-09-24T00:50:09Z | |
| dc.date.issued | 2024-08-26 | |
| dc.identifier.uri | http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15450 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-10692 | |
| dc.format.extent | 76 | de |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Modulation der T-Zell-Infiltration und der Aktivierung von Makrophagen/Mikroglia bei der EAE durch zellspezifische Deletion des Arylkohlenwasserstoffrezeptors (AhR) | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Stadelmann-Nessler, Christine Prof. Dr. | |
| dc.date.examination | 2024-08-28 | de |
| dc.description.abstracteng | To better understand the pathomechanisms underlying multiple sclerosis, the role of the Ah receptor
(AhR) in immune cell recruitment to the CNS was investigated using the murine experimental
autoimmune encephalomyelitis (EAE) model. AhR-signaling modulates the differentiation and
function of different cell populations that play an important role in neuroinflammation. AhR
expression is apparent in immune cells, in particular in B-cells, T-cells, plasma cells and dendritic cells
(DCs) as well as in the glial cell populations monocytes / macrophages and astrocytes. Highest
expression levels can be found in the astrocytic cell population.
Previous studies on EAE mice revealed that an AhR deletion leads to a reduced overall immune
response. To find out which cell population is mainly responsible for this effect, cell-specific AhR
knock-out mice were used (CD4+ T-cells, regulatory T-cells, DCs and astrocytes). In these mice, an
active EAE was induced and the clinical course of the EAE was measured using an established scoring
system of the EAE symptoms. Further histologic and immunohistochemical analysis was performed
to quantify the lesion size, the T-cell infiltration and macrophage- / microglia-activation.
The most pronounced effect was found in mice with an AhR-knock-out in CD4+ T-cells. Compared to
control animals, those animals showed a milder clinical course, a reduced size of demyelinated
lesions, decreased T-cell infiltration, as well as a reduced macrophage-/microglia-activation. | de |
| dc.contributor.coReferee | Odoardi, Francesca Prof. Dr. | |
| dc.contributor.thirdReferee | Kauffmann, Philipp Prof. Dr. | |
| dc.subject.eng | Experimental Autoimmune Encephalomyelitis (EAE) | de |
| dc.subject.eng | Multiple Sclerosis (MS) | de |
| dc.subject.eng | Aryl-Hydrocarbon-Receptor (AhR) | de |
| dc.subject.eng | T-cells | de |
| dc.subject.eng | astrocytes | de |
| dc.subject.eng | macrophages | de |
| dc.subject.eng | neuroinflammation | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-ediss-15450-1 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674) | de |
| dc.description.embargoed | 2024-09-24 | de |
| dc.identifier.ppn | 1899863745 | |
| dc.notes.confirmationsent | Confirmation sent 2024-08-26T11:45:01 | de |