dc.contributor.advisor | Conradi, Lena-Christin PD Dr. Dr. | |
dc.contributor.author | Fleischer, Johannes Robert | |
dc.date.accessioned | 2024-09-10T12:35:12Z | |
dc.date.available | 2024-10-18T00:50:10Z | |
dc.date.issued | 2024-09-10 | |
dc.identifier.uri | http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15474 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-10729 | |
dc.format.extent | 83 | de |
dc.language.iso | eng | de |
dc.subject.ddc | 610 | de |
dc.title | Evaluation of desmoplastic and replacement type histopathological growth patterns of colorectal cancer liver metastases at single-cell resolution | de |
dc.type | cumulativeThesis | de |
dc.contributor.referee | Papantonis, Argyris Prof. Dr. | |
dc.date.examination | 2024-09-20 | de |
dc.description.abstracteng | This thesis project evaluated molecular differences between desmoplastic and replacement
colorectal liver metastases, with the focus on the heterogeneity between ECs in livers
colonized by CRCLM. Stratifying the sample specimen according to their mode of blood
irrigation into sprouting angiogenesis or vessel cooption, I used a single cell RNA sequencing
pipeline to establish a comprehensive dataset that captured all main cell populations.
After conducting extensive literature research and publishing my findings, I focused on
studying the heterogeneity of endothelial cells in the adjacent liver. This exploration revealed
a connection between the HGP/mode of vascularization and the presence of a unique
capillary phenotype that had not been previously described.
This discovery implicates a possible contribution of the host microenvironment to the
development of different phenotypes. Moreover, I discussed if this discovery might be
correlating to a previously not proven association of liver fibrosis and the observation of
desmoplastic CRCLM. Further research might use these findings to evaluate possible
mechanistical connections between cancer cells and the endothelial cells or the possibility to
tailor targeted personalized treatment regimes. | de |
dc.contributor.coReferee | Dobbelstein, Matthias Prof. Dr. | |
dc.subject.eng | Cancer | de |
dc.subject.eng | Colorectal Liver Metastases | de |
dc.subject.eng | Liver Metastases | de |
dc.subject.eng | Vessel | de |
dc.subject.eng | Vessel Co-option | de |
dc.subject.eng | Oncology | de |
dc.subject.eng | Sprouting Angiogenesis | de |
dc.identifier.urn | urn:nbn:de:gbv:7-ediss-15474-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Chirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968) | de |
dc.subject.gokfull | Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674) | de |
dc.description.embargoed | 2024-10-18 | de |
dc.identifier.ppn | 190241232X | |
dc.identifier.orcid | 0000-0003-4374-2971 | de |
dc.notes.confirmationsent | Confirmation sent 2024-09-10T12:45:01 | de |