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Die Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinom

dc.contributor.advisorEllenrieder, Volker Prof. Dr.
dc.contributor.authorTirilomi-Mascher, Anna Eleonora Angelika
dc.date.accessioned2024-09-24T16:19:10Z
dc.date.available2024-10-23T00:50:09Z
dc.date.issued2024-09-24
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/15505
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-10754
dc.format.extent89de
dc.language.isodeude
dc.subject.ddc610de
dc.titleDie Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinomde
dc.typedoctoralThesisde
dc.contributor.refereeEllenrieder, Volker Prof. Dr.
dc.date.examination2024-09-25de
dc.description.abstractengPancreatic carcinoma is one of the most aggressive solid tumour types and is characterized by pronounced molecular heterogeneity. Research is continuing into molecularly definable subgroups that are suitable for targeted, individualized treatment. In particularly aggressive subgroups of pancreatic cancer, glycogen synthase kinase 3β (GSK3β) has been identified, which is associated with tumor cell proliferation, de-differentiation, progression and resistance to chemotherapy. An oncogenic effect of GSK3β has been demonstrated in multiple tumor entities. Using established murine and human cell lines as well as primary cell lines isolated from PDX tumors (patient-derived xenografts), the role of glycogen synthase kinase 3β in the regulation of DNA damage was investigated.de
dc.contributor.coRefereeStröbel, Philipp Prof. Dr.
dc.subject.gerPankreaskarzinomde
dc.subject.gerGSK3βde
dc.subject.gerChemotherapiede
dc.subject.gerChemotherapieresistenzde
dc.subject.engpancreatic cancerde
dc.subject.engGSK3βde
dc.subject.engchemotherapyde
dc.subject.engchemotherapy resistancede
dc.identifier.urnurn:nbn:de:gbv:7-ediss-15505-7
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.description.embargoed2024-10-23de
dc.identifier.ppn1903565219
dc.creator.birthnameTirilomide
dc.notes.confirmationsentConfirmation sent 2024-09-24T19:45:01de


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