Die Assoziation zwischen niedrigem Blutdruck und der Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) im Verlauf von Kindheit und Adoleszenz.

Auswertungen einer bevölkerungsbasierten Beobachtungsstudie über einen zehnjährigen Verlauf

by Jan Philipp Schulz
Doctoral thesis
Date of Examination:2024-11-20
Date of issue:2024-11-18
Advisor:Prof. Dr. Luise Poustka
Referee:Prof. Dr. Luise Poustka
Referee:Prof. Dr. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-10874

 

 

Files in this item

Name:Schulz_Jan Philipp_Dissertation_ohneCV.pdf
Size:1.80Mb
Format:PDF

This file will be freely accessible after 2024-12-18.

Abstract

English

Attention deficit hyperactivity disorder (ADHD) is one of the most common behavioral disorders in childhood and adolescence, associated with significant psychosocial impairment. The basic pathophysiology of ADHD may be related, at least in part, to a disturbance in autonomic arousal processes, which could not only influence the core symptoms of the dis- order but also lead to blood pressure abnormalities due to altered arousal regulation. In this work, long-term changes in blood pressure were examined in children and adolescents with ADHD through young adulthood. A total of 10,960 children and adolescents, aged 7 to 17 years at baseline, had blood pressure values compared between 1,219 individuals with and 9,741 individuals without ADHD over a 10-year period, using data from the nationwide Children and Adolescent Health Survey (KiGGS). At baseline, children and adolescents with ADHD had significantly lower blood pressure compared to the group without ADHD, while this difference was no longer detectable at follow-up 10 years later. These developmental changes in blood pressure from adolescence to early adulthood may be due to changes in the state of autonomic arousal that likely modulate the pathophysiology of ADHD. The present analysis indicated that hemodynamic parameters should be considered to better understand the pathophysiology of ADHD in the developmental context of the subcortical arousal hypothesis.
Keywords: KiGGS; ADHD; Blood Pressure