Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas

by Xiaoxue Li
Doctoral thesis
Date of Examination:2024-12-12
Date of issue:2024-12-02
Advisor:Prof. Dr. Philipp Ströbel
Referee:Prof. Dr. Philipp Ströbel
Referee:Prof. Dr. Volker Ellenrieder
Persistent Address: http://dx.doi.org/10.53846/goediss-10916

 

 

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Abstract

English

Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), Forkhead Box Protein M1 (FOXM1), and Cyclin B1 (CCNB1) in conferring cisplatin resistance within thymic epithelial tumors. We find these proteins FOXM1, GPX1, and CCNB1 as potential regulators in resistance mechanisms. GPX1 mitigates oxidative stress through ROS regulation, FOXM1 facilitates DNA repair and modulates cell cycle progression, and CCNB1 regulates mitotic transitions critical for cell survival under chemotherapeutic pressure. Our findings show the molecular pathways under cisplatin resistance, providing insights into potential biomarkers and therapeutic targets for combating drug resistance in thymic cancers. These discoveries hold promise for advancing precision oncology approaches in the treatment of refractory thymic epithelial malignancies.
Keywords: malignant thymomas and thymic carcinomas; cisplatin resistance; CCNB1; GPX1; FOXM1
 
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