Osteoporose bei Mastozytose: Retrospektive Analyse von Betroffenen kutaner oder systemischer Form

Osteoporosis in mastocytosis: Retrospective analysis in patients with the cutaneous or the systemic form

by Christof Wilke
Doctoral thesis
Date of Examination:2024-12-11
Date of issue:2024-12-09
Advisor:Prof. Dr. Heide Siggelkow
Referee:Prof. Dr. Heide Siggelkow
Referee:PD Dr. Daniel Hoffmann
Persistent Address: http://dx.doi.org/10.53846/goediss-10922

 

 

Files in this item

Name:finale Dissertation Osteoporose bei Mastozyt...pdf
Size:1.98Mb
Format:PDF

This file will be freely accessible after 2025-12-10.

Abstract

English

Mastocytosis is an infiltration of clonal mast cells either in the skin (cutaneous mastocytosis; CM) or at least one extracutaneous organ (systemic mastocytosis; SM). The most frequent systemic subtype is the indolent systemic mastocytosis (ISM). Bone loss is a typical symptome of the rare disease. The occurrence, especially the pathogenesis, are not completely understood. In the retrospective study clinical data of 104 patients of the MVZ Endokrinologikum Göttingen with diagnosed or suspected mastocytosis were analyzed. In ISM 42 % had an osteoporosis while 38 % of the CM patients had an osteoporosis. The tryptase level was significantly higher in ISM than CM (p-value < 0,001). No significant differences were found in bone markers. Bone mineral densities (BMD) and trabecular bone scores (TBS) were lower in ISM than CM but significance was not reached. ISM patients with a KIT-mutation had significantly more vertebral fractures than with the wild-type gene (p-value < 0,05). ISM patients with skin lesions had a significant higher T-score at the right femur (p-value < 0,01) and femoral neck (p-value < 0,05) than patients without skin lesions. These differences were not found in CM patients. ISM patients showed higher tryptase levels, more back pain and typically multiple vertebral fractures. KIT-wild-type and skin lesions are positive prognostic factors in ISM. These do not apply for CM. Specific antiosteoporotic treatment increased BMD in mastocytosis patients. Fractures could not be completely prevented.
Keywords: mastocytosis; osteoporosis
Schlagwörter: Mastozytose; Osteoporose