Mechanisms of chromosome segregation in mammalian oocytes

Saha, Debojit

dc.contributor.advisor	Schuh, Melina Prof. Dr.
dc.contributor.author	Saha, Debojit
dc.date.accessioned	2024-12-10T17:39:12Z
dc.date.issued	2024-12-10
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15670
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-10910
dc.format.extent	156	de
dc.language.iso	eng	de
dc.subject.ddc	570	de
dc.title	Mechanisms of chromosome segregation in mammalian oocytes	de
dc.type	doctoralThesis	de
dc.contributor.referee	Bohnsack, Markus Prof. Dr.
dc.date.examination	2023-12-18	de
dc.description.abstracteng	Errors in chromosome segregation in human females often result in eggs with the wrong number of chromosomes, a condition known as aneuploidy. The rate of aneuploidy increases dramatically in women with age, particularly from the mid-30s. Cohesins that hold sister chromatids together are lost from aged oocytes, which results in premature separation of sister chromatids, a leading cause of aneuploidy. However, the mechanism underlying the age-related loss of sister chromatid cohesion remains unclear. In this study, we used high-resolution imaging of mammalian oocytes to identify factors that play a major role in chromosome segregation during meiotic divisions. We also used microscopy, genetics, and proteomics to systematically investigate how changes in these factors with age are associated with increased oocyte aneuploidy. Taken together, the data presented in this thesis provide new insights into the poorly understood process of age-related infertility in women, which may help in the development of therapeutic strategies to reduce aneuploidy-causing errors in mammalian oocytes.	de
dc.contributor.coReferee	Günesdogan, Ufuk Dr.
dc.contributor.thirdReferee	Lenart, Peter Dr.
dc.contributor.thirdReferee	Faesen, Alex Dr.
dc.contributor.thirdReferee	Oudelaar, Marieke Dr.
dc.subject.eng	Aneuploidy	de
dc.subject.eng	Age-related infertility	de
dc.subject.eng	Cohesin	de
dc.subject.eng	Chromosome segregation errors	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15670-3
dc.date.embargoed	2025-12-17
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.description.embargoed	2025-12-17	de
dc.identifier.ppn	1911943235
dc.identifier.orcid	https://orcid.org/0009-0008-3927-0311	de
dc.notes.confirmationsent	Confirmation sent 2024-12-10T19:45:02	de