Strategies for decreasing aneuploidy in mammalian oocytes

Yusuf, Halima

dc.contributor.advisor	Schuh, Melina Prof. Dr.
dc.contributor.author	Yusuf, Halima
dc.date.accessioned	2025-01-10T17:23:05Z
dc.date.issued	2025-01-10
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15732
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11002
dc.format.extent	142	de
dc.language.iso	eng	de
dc.subject.ddc	570	de
dc.title	Strategies for decreasing aneuploidy in mammalian oocytes	de
dc.type	cumulativeThesis	de
dc.contributor.referee	Dobbelstein, Matthias Prof. Dr.
dc.date.examination	2024-02-21	de
dc.description.abstracteng	Female mammals experience a decline in fertility with age that has been attributed to the progressive depletion of the finite ovarian reserve and an increase in the incidence of aneuploid oocytes. Aneuploid oocytes can give rise to aneuploid embryos that are often non-viable, resulting in pregnancy loss. As such, many women over the age of 35 will struggle to conceive. Aneuploidy in oocytes arises from chromosome segregation errors during meiosis. Studies in mice show that the cohesin complex, which stabilizes bivalents and chromosomes, is gradually lost from chromosomes with age, causing changes in bivalent and chromosome structure that prime for missegregation events. Repurposing this knowledge towards clinical application has remained purely aspirational, however. In this context, my thesis focused on developing molecular tools and strategies for reducing aneuploidy in mouse and human oocytes. The data presented within this thesis represent progress towards therapies that target age-related infertility in humans.	de
dc.contributor.coReferee	Schuh, Melina Prof. Dr.
dc.subject.eng	cohesin	de
dc.subject.eng	Aneuploidy	de
dc.subject.eng	oocyte	de
dc.subject.eng	maternal age effect	de
dc.subject.eng	infertility	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15732-7
dc.date.embargoed	2026-02-20
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.description.embargoed	2026-02-20	de
dc.identifier.ppn	191485053X
dc.notes.confirmationsent	Confirmation sent 2025-01-10T19:45:01	de

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1218]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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