Stellenwert der Leberbiopsie zur Klärung der Ätiologie unklarer chronischer Leberwerterhöhung

Krämer, Antonia Louise

dc.contributor.advisor	Petzold, Golo PD Dr.
dc.contributor.author	Krämer, Antonia Louise
dc.date.accessioned	2025-01-31T17:36:34Z
dc.date.available	2025-04-28T00:50:08Z
dc.date.issued	2025-01-31
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15785
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11037
dc.format.extent	78	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Stellenwert der Leberbiopsie zur Klärung der Ätiologie unklarer chronischer Leberwerterhöhung	de
dc.type	doctoralThesis	de
dc.contributor.referee	Bremmer, Felix Prof. Dr.
dc.date.examination	2025-03-31	de
dc.description.abstracteng	Elevated liver enzymes are common and require thorough investigation to enable timely treatment and prevent fibrosis progression. Advances in diagnostics have reduced the need for liver biopsies, but they remain valuable in unclear cases. This dissertation retrospectively analyzed clinical, serological, imaging, and histopathological data from 84 patients biopsied at UMG between 2015 and 2021 for chronically unclear elevated liver enzymes or cryptogenic cirrhosis. The aim was to evaluate diagnostic clarification rates and underlying causes.This study found that biopsies clarified the cause in under half of cases, influencing treatment particularly through immunosuppressive therapy and lifestyle changes. Clinical data lacked predictive value for etiological clarification, likely due to heterogeneity among diagnostic groups and nonspecific predictors. Given the clarification rate, therapeutic impact, and complication rates within established reference values, liver biopsy remains a justified diagnostic tool for chronically unclear elevated liver enzymes.	de
dc.contributor.coReferee	Kube, Dieter Prof. Dr.
dc.subject.eng	Liver biopsy	de
dc.subject.eng	elevated liver enzymes	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15785-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)	de
dc.description.embargoed	2025-04-28	de
dc.identifier.ppn	1916133967
dc.notes.confirmationsent	Confirmation sent 2025-01-31T19:45:01	de

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