• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Biologie und Psychologie (inkl. GAUSS)
  • Item View
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Biologie und Psychologie (inkl. GAUSS)
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Single-cell studies of mammalian ovaries

by Sarah Mae Penir
Doctoral thesis
Date of Examination:2024-02-12
Date of issue:2025-01-31
Advisor:Prof. Dr. Melina Schuh
Referee:Prof. Dr. Melina Schuh
Referee:Prof. Dr. Anne-Christin Hauschild
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-11058

 

 

Files in this item

Name:Penir_PhD_labversion.pdf
Size:60.6Mb
Format:PDF
Description:Doctoral thesis

This file will be freely accessible after 2026-02-11.


Abstract

English

Ovarian aging progresses more rapidly than in other organs. Female fertility declines exponentially after the age of 35, and as women increasingly delay childbearing, it is paramount to understand the underlying etiology and mechanisms of ovarian aging. In my doctorate, I uncovered several key features of aging by using a combination of transcriptomic and proteomic approaches. At the transcriptomic level, ovarian aging is characterized by changes leading to oxidative stress, decreased progesterone secretion, and increased AP-1 signaling. In addition, I provide evidence that multiparity can slow down advanced maternal aging by reducing these age-related biological processes. Large-scale proteomic profiling revealed that ovaries have a 10-fold higher fraction of extremely long-lived proteins, and that with age, extensive proteome remodeling leads to the decrease in the long-lived proteins of the proteostasis network. Taken together, this body of work provides an important foundation for the large-scale, high-throughput understanding of ovarian aging at the transcriptomic and proteomic levels.
Keywords: ovarian aging; bioinformatics; scRNAseq; oocyte; ovary
 


Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information | Accessibility
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]