Development of a Bone Adhesive Material based on Diazirinyl-Collagen Mimetic Peptides

Castillo Orenes, Maria

dc.contributor.advisor	Walker, Johannes C. L. Prof. Dr.
dc.contributor.author	Castillo Orenes, Maria
dc.date.accessioned	2025-02-05T17:36:35Z
dc.date.issued	2025-02-05
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15797
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11061
dc.format.extent	195	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	540	de
dc.title	Development of a Bone Adhesive Material based on Diazirinyl-Collagen Mimetic Peptides	de
dc.type	doctoralThesis	de
dc.contributor.referee	Walker, Johannes C. L. Prof. Dr.
dc.date.examination	2024-12-13	de
dc.description.abstracteng	The treatment of small and inaccessible bone fractures with metallic implants is challenging. One potential solution to this issue is the use of an adhesive to adhere the affected fragments. In the search for new biocompatible bone adhesives, collagen-based materials have been widely explored as collagen type I is the major organic component of the extracellular matrix in bone tissue. However, immunogenic responses complicate the use of collagen derived from animal tissues at the clinical level. Collagen Mimetic Peptides (CMPs) are currently being investigated as candidates for the synthesis of artificial extracellular matrix scaffolds due to their reduced toxicity and ability to hybridise with natural collagen. Additionally, the use of a non-toxic crosslinker that can be activated on demand and enhance bone adhesive strength has been proposed. Diazirines are small heterocyclic groups that can cleave under UV irradiation to form electrophilic carbenes, which are known to undergo rapid crosslinking reactions in biological systems. This thesis explores and proposes strategies for the full chemical synthesis of a bone adhesive material resulting from the combination of CMPs and diazirines.	de
dc.contributor.coReferee	Schilling, Arndt Prof. Dr
dc.contributor.thirdReferee	Janshoff, Andreas Prof. Dr.
dc.contributor.thirdReferee	Simeth, Nadja Prof. Dr.
dc.contributor.thirdReferee	Tittmann, Kai Prof. Dr.
dc.contributor.thirdReferee	Frauendorf, Holm Dr.
dc.subject.eng	Collagen Mimetic Peptides	de
dc.subject.eng	Diazirines	de
dc.subject.eng	Solid Phase Peptide Synthesis	de
dc.subject.eng	Hydrogels	de
dc.subject.eng	Bone adhesives	de
dc.subject.eng	Collagen	de
dc.subject.eng	Photocrosslinking	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-15797-3
dc.date.embargoed	2026-02-05
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.description.embargoed	2026-02-05	de
dc.identifier.ppn	1916619940
dc.notes.confirmationsent	Confirmation sent 2025-02-05T19:45:02	de

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