| dc.contributor.advisor | Groß, Uwe Prof. Dr. | |
| dc.contributor.author | Monnheimer, Mathieu | |
| dc.date.accessioned | 2025-02-06T11:26:11Z | |
| dc.date.issued | 2025-02-06 | |
| dc.identifier.uri | http://resolver.sub.uni-goettingen.de/purl?ediss-11858/15801 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-11056 | |
| dc.format.extent | 111 | de |
| dc.language.iso | eng | de |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | A cross-sectional study on the impact of herbal medicine on the prevalence of bacterial and fungal pathogens in wound infections and surgical site infections in rural Ghana | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Groß, Uwe Prof. Dr. | |
| dc.date.examination | 2025-03-12 | de |
| dc.description.abstracteng | This study was performed to get a better understanding about the use of traditional herbal
medicine on wound infection in Ghana, and to analyze possible effects on wound pathogen
composition and pathogen resistance. Our results demonstrate that traditional herbal
medicine is still widely used in rural Ghana. This includes the use of medical plants described
previously, especially Alchornea cordifolia. There was a significant effect on pathogen
prevalence in wounds treated with traditional herbal medicine with regard to key bacterial
and fungal pathogens, but no general difference in pathogen distribution. Herbal medicine
products were often contaminated with bacterial and fungal pathogens, which may trigger
infection of wounds. With 94.6 %, a high prevalence of wound infections resulting from
bacterial and fungal pathogens could be determined. Although infection rates were highest
in chronic wounds, a high prevalence (24.9 %) of hospital-acquired surgical-site infections
was also demonstrated. Infected wounds were mainly of polymicrobial composition. With
more than 60 %, the majority of pathogens were gram-negative bacteria consisting of
Enterobacterales and non-fermenters. Nearly every third wound was infected with grampositive
bacteria. The majority of S. aureus was shown to produce the virulence factor PVL.
Together with the already high rates of combined fluoroquinolone and cephalosporin
resistance in most gram-negative bacterial species found in wound infections, the novel
appearance of PVL-positive MRSA and new emergence and nosocomial spread of
carbapenem-resistant A. baumannii in the study region are worrying. Anaerobic and fungal
pathogens requiring challenging polymicrobial diagnostics were detected in small numbers,
including metronidazole-resistant B. fragilis. While sequence typing has revealed new A.
baumannii strains, it can only be assumed that lack of diagnostics, improper treatment and
widely available over-the-counter antibiotics are contributing factors to the rise of new
antibiotic resistances. Together, these results emphasize the importance of permanent
availability of local microbial diagnostics and continuous surveillance of the local resistance
situation. Still not completely resolved is the precise reason for the emergence of new
antibiotic resistances. Finally, access to effective antibiotic drugs according to specific
resistance profile needs to be established. | de |
| dc.contributor.coReferee | Schilling, Arndt Prof. Dr | |
| dc.contributor.thirdReferee | Frank, Jorge Alberto Prof. Dr. | |
| dc.subject.eng | Microbiology | de |
| dc.subject.eng | Antimicrobial resistance | de |
| dc.subject.eng | Herbal medicine | de |
| dc.subject.eng | Wound infection | de |
| dc.subject.eng | Ghana | de |
| dc.subject.eng | AMR | de |
| dc.subject.eng | Carbapenemase | de |
| dc.subject.eng | MRSA | de |
| dc.subject.eng | Acinetobacter baumannii | de |
| dc.subject.eng | Clinical Microbiology | de |
| dc.subject.eng | Tropical medicine | de |
| dc.subject.eng | Alchornea cordifolia | de |
| dc.subject.eng | Polymicrobial infection | de |
| dc.subject.eng | PVL | de |
| dc.subject.eng | chronic wounds | de |
| dc.subject.eng | traditional medicine | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-ediss-15801-1 | |
| dc.date.embargoed | 2026-03-11 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizinische Mikrobiologie / Medizinische Virologie / Medizinische Mykologie / Infektionskrankheiten / Hygiene / Impfung / Parasitologie / Tropenmedizin - Allgemein- und Gesamtdarstellungen (PPN619875356) | de |
| dc.description.embargoed | 2026-03-11 | de |
| dc.identifier.ppn | 1916728170 | |
| dc.identifier.orcid | 0000-0003-0366-6644 | de |
| dc.notes.confirmationsent | Confirmation sent 2025-02-06T11:45:01 | de |