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Multisensory integration under visual target uncertainty during planning of reaching movements

dc.contributor.advisorGail, Alexander Prof. Dr.
dc.contributor.authorAmann, Lukas Karl-Heinz
dc.date.accessioned2025-02-25T18:10:46Z
dc.date.available2025-03-04T00:50:04Z
dc.date.issued2025-02-25
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?ediss-11858/15850
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-11096
dc.format.extent161de
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570de
dc.titleMultisensory integration under visual target uncertainty during planning of reaching movementsde
dc.typedoctoralThesisde
dc.contributor.refereeGail, Alexander Prof. Dr.
dc.date.examination2024-11-06de
dc.description.abstractengMovements are fundamental to human interaction and everyday function, relying on the integration of multiple sensory inputs for precise planning and execution. However, sensory uncertainty, particularly in the visual domain, can impair motor control, and the loss of proprioception due to injury or disease further exacerbates these deficits. Understanding how the brain integrates uncertain sensory information is essential for advancing the development of assistive technologies. This thesis addresses two main questions. The first question examines whether artificial vibrotactile stimulation can compensate for visual uncertainty in goal-directed reaching. By providing additional sensory cues about target location, I show that human participants integrate artificial somatosensory signals in a manner consistent with Bayesian optimal integration, improving movement accuracy despite unreliable vision. The second question focuses on the neural consequences of visual uncertainty by recording electrophysiological activity in the motor cortex of nonhuman primates. High uncertainty in target position disrupted motor goal encoding during movement planning, while feedback uncertainty impairs motor goal representations only when it is task critical, i.e., when having to rely on the sensory feedback and no other more reliable sensory modalities are available. Additionally, target uncertainty is encoded along near-orthogonal neural dimensions, potentially enabling separation of decision-making and movement-related processes. Together, these studies provide novel insights into the neural mechanisms of multisensory integration and motor planning under visual uncertainty.de
dc.contributor.coRefereeScherberger, Hansjörg Prof. Dr.
dc.subject.engMovement planningde
dc.subject.engVisual uncertaintyde
dc.subject.engMultisensory integrationde
dc.subject.engPsychophysicsde
dc.subject.engElectrophysiologyde
dc.subject.engVibrotactile stimulationde
dc.subject.engMotor cortexde
dc.identifier.urnurn:nbn:de:gbv:7-ediss-15850-2
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullBiologie (PPN619462639)de
dc.description.embargoed2025-03-04de
dc.identifier.ppn1918667209
dc.notes.confirmationsentConfirmation sent 2025-02-25T19:45:01de


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