Der Einfluss von medizinischem Kaltplasma auf kutanes Gewebe und Wunden
by Murat Tanyeli
Date of Examination:2025-04-17
Date of issue:2025-03-20
Advisor:Prof. Dr. Gunther Felmerer
Referee:Prof. Dr. Gunther Felmerer
Referee:Prof. Dr. Lutz Kretschmer
Referee:PD Dr. Jens Sperling
Persistent Address:
http://dx.doi.org/10.53846/goediss-11148
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Abstract
English
In the present study, the effects of medical cold plasma on human skin were investigated. On the one hand, the focus was on the impact of medical cold plasma on measurable parameter changes, particularly the microcirculation of intact skin; on the other hand, the influence of medical cold plasma on wound healing was examined. These investigations were conducted in two separate studies. In the first study, the influence of medical cold plasma on intact skin was investigated. Ten participants were included in the study. The changes in local tissue factors were observed through the combined application of medical cold plasma and the mechanical pressure required for it, compared to the application of mechanical pressure alone without plasma treatment and a control measurement with no external manipulation. The observed tissue factors were blood flow, blood flow velocity, postcapillary oxygen saturation, relative hemoglobin content, pH level, skin moisture, and temperature. The observation period was 60 minutes after plasma application, with applications lasting 90, 180, and 270 seconds. It was shown that a significant increase in local microcirculation parameters was achieved through the application of medical cold plasma, but not by mechanical pressure alone. For an application duration of 270 seconds, an increase in relative hemoglobin content by 5.1%, postcapillary oxygen saturation by 9.1%, and blood flow by 105.5% was demonstrated. In the second study, the influence of medical cold plasma on hard-to-heal wounds and acute wounds with at least one risk factor for the development of wound healing disorders or chronic wounds was investigated in terms of wound size and healing duration. The results were compared to wound healing based on literature data under standard wound care. The observation period for this study was 2 years. Twenty participants with a total of 27 wounds were included in the study; of these, 8 were acute wounds and 19 were hard-to-heal wounds. The participants were treated with medical cold plasma three times a week for 180 seconds each, over the course of several months. Wound size measurements were taken after 4 weeks, 12 weeks, and upon complete wound closure. The average age of the wounds was 49 months. The average wound area was 15 cm². After an average observation period of 14.2 weeks, all acute wounds and 68% of the hard-to-heal wounds had healed. 21% of the hard-to-heal wounds had not fully closed by the end of the observation period; however, their wound size had decreased by 80%. 11% of the hard-to-heal wounds were discontinued during therapy. In summary of both studies, we were able to demonstrate that the application of medical cold plasma not only enhances the local microcirculation of intact skin but also contributes to improving wound healing in both acute and hard-to-heal wounds.
Keywords: plasma medicine; cold atmospheric plasma; medical cold plasma; wound care; wound healing; hard-to-heal wonds
