Enantioselective Electrochemical C–H Activation with Cobalt, Nickel, and Iron

by Tristan von Münchow
Doctoral thesis
Date of Examination:2025-03-13
Date of issue:2025-04-04
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Konrad Koszinowski
Referee:Prof. Dr. Dietmar Stalke
Referee:Prof. Dr. Dr. Lutz Tietze
Referee:Dr. Daniel Janßen-Müller
Referee:Dr. Holm Frauendorf
Persistent Address: http://dx.doi.org/10.53846/goediss-11186

 

 

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Abstract

English

The enantioselective functionalization of otherwise inert C–H bonds to assemble chiral molecules has become an increasingly powerful tool in molecular synthesis. In spite of significant advances in this domain, the reported approaches commonly relied on precious metal catalysts, while strategies employing 3d transition metal-catalysis remained underexplored, generally featuring major limitations such as the use of chemical oxidants or organometallic additives, compromising the overall sustainability. In sharp contrast, this thesis showcases the enabling potential of the merger of electrosynthesis with enantioselective 3d transition metal-catalyzed C–H activation. Hence, powerful and resource-economic approaches for the assembly of versatile chiral compounds were disclosed.
Keywords: Enantioselective; Electrocatalysis; C–H Activation; Cobalt; Nickel; Iron