2D-Shear-wave Elastographie zur Evaluation der Lebersteifigkeit bei systemischer Sklerodermie und primärer biliärer Cholangitis

Korendovych, Viktor

dc.contributor.advisor	Korsten, Peter Dr.
dc.contributor.author	Korendovych, Viktor
dc.date.accessioned	2025-05-26T15:49:10Z
dc.date.available	2025-06-30T00:50:09Z
dc.date.issued	2025-05-26
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/16018
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11251
dc.format.extent	63	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	2D-Shear-wave Elastographie zur Evaluation der Lebersteifigkeit bei systemischer Sklerodermie und primärer biliärer Cholangitis	de
dc.type	doctoralThesis	de
dc.contributor.referee	Amanzada, Ahmad Prof. Dr.
dc.date.examination	2025-06-02	de
dc.description.abstracteng	2D Shear-wave elastography (2D-SWE) is a simple, proven, and inexpensive method for determining the liver stiffness (LS). In the present study, we examined the LS using 2D-SWE in patients with systemic sclerosis (SSc) and overlap of systemic sclerosis and primary biliary cholangitis (SSc-PBC), and compared the results with patients with primary biliary cholangitis (PBC) and healthy subjects. In summary, patients with SSc without PBC have normal LS, which corresponds to the values of a healthy cohort. Our results demonstrate that SSc-PBC is more common in anti-centromere antibody-positive limited cutaneous SSc and is associated with increased LS. PBC appears to be the leading cause of increased LS in SSc patients. Due to the small number of patients in our study, further studies should be performed to confirm our results. Although 2D-SWE may be used as a simple non-invasive screening tool to determine LS in cases of suspected liver involvement in SSc, additional studies combining 2D-SWE, magnetic resonance imaging, and liver biopsy with histological examination may be helpful to clarify the etiology of elevated LS in some SSc patients without confirmed PBC. Considering antibody-negative PBC or other forms of liver involvement in SSc, liver biopsy could be considered in selected SSc patients with elevated LS, especially if the diagnostic criteria for PBC are not met without histological confirmation.	de
dc.contributor.coReferee	Petzold, Golo PD Dr.
dc.subject.ger	Systemische Sklerodermie	de
dc.subject.ger	primäre biliäre Cholangitis	de
dc.subject.ger	Lebersteifigkeit	de
dc.subject.ger	2D-Shear-wave Elastographie	de
dc.subject.ger	Overlap	de
dc.subject.eng	Systemic sclerosis	de
dc.subject.eng	primary biliary cholangitis	de
dc.subject.eng	liver stiffness	de
dc.subject.eng	2D-shear wave elastography	de
dc.subject.eng	overlap	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-16018-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2025-06-30	de
dc.identifier.ppn	1926887999
dc.creator.birthname	Korendovych	de
dc.notes.confirmationsent	Confirmation sent 2025-05-26T19:45:01	de

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