Zerebrale Kartierung der neuronalen Redox-Veränderung in einem Maus-Modell für das Rett-Syndrom

Woeste, Hendrik

dc.contributor.advisor	Müller, Michael Prof. Dr.
dc.contributor.author	Woeste, Hendrik
dc.date.accessioned	2025-06-24T06:39:36Z
dc.date.available	2025-08-05T00:50:08Z
dc.date.issued	2025-06-24
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/16069
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11348
dc.format.extent	69	de
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	610	de
dc.title	Zerebrale Kartierung der neuronalen Redox-Veränderung in einem Maus-Modell für das Rett-Syndrom	de
dc.type	doctoralThesis	de
dc.title.translated	Cerebral mapping of neuronal redox changes in a mouse model of Rett syndrome	de
dc.contributor.referee	Müller, Michael Prof. Dr.
dc.date.examination	2025-07-08	de
dc.description.abstracteng	As part of this study, changes in the neuronal redox balance in the brains of Rett mice are mapped and correlated with the progression of Rett syndrome. Fluorescence microscopy techniques (primarily ratiometric CCD camera imaging and two-photon microscopy) were used along with the optical redox indicator roGFP1. This redox indicator is already stably expressed in the Rett mice, allowing for optical analyses to be performend directly on acutely isolated brain tissue without the need for prior transfection or transduction. With this method it was possible to document the changes in the neuronal redox balance in different brain areas, in different ages and genotypes of mice.	de
dc.contributor.coReferee	Bogeski, Ivan Prof. Dr.
dc.contributor.thirdReferee	Kaufmann, Philipp Prof. Dr.
dc.subject.eng	Rett syndrome	de
dc.subject.eng	roGFP	de
dc.subject.eng	fluorescence microscopy	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-16069-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	OK-MEDIZIN	de
dc.subject.gokfull	Physiologie / Pathophysiologie - Allgemein- und Gesamtdarstellungen (PPN619875283)	de
dc.description.embargoed	2025-08-05	de
dc.identifier.ppn	1929134584
dc.notes.confirmationsent	Confirmation sent 2025-06-24T06:45:01	de

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