Einfluss örtlicher und zeitlicher Auflösung auf die Analyse von Strain- und Strainrate-Parametern und deren Reproduzierbarkeit in der Feature-Tracking-basierten Deformationsanalyse in der kardialen MRT

by Jonas Schmidt-Rimpler
Doctoral thesis
Date of Examination:2025-08-06
Date of issue:2025-07-28
Advisor:PD Dr. Sören J. Backhaus
Referee:PD Dr. Sören J. Backhaus
Referee:PD Dr. Michael Steinmetz
Sponsor:Deutsche Herzstiftung e.V.
Persistent Address: http://dx.doi.org/10.53846/goediss-11394

 

 

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Abstract

English

Background: Myocardial deformation assessment using cardiac magnetic resonance feature tracking (CMR-FT) provides prognostic insights beyond conventional volumetric analyses. While ventricular CMR-FT is well-established, atrial deformation analysis has gained increasing interest. However, optimal spatial and temporal resolution parameters for reliable functional assessment of both atria and ventricles remain undefined. Methods: CMR-FT was performed in 12 healthy volunteers and 9 ischemic heart failure (HF) patients. Cine sequences were acquired using different temporal (20, 30, 40 and 50 frames/cardiac cycle) and spatial resolution parameters (high 1.5 × 1.5 mm in plane and 5 mm slice thickness, standard 1.8 × 1.8 × 8 mm and low 3.0 × 3.0 × 10 mm). Inter- and intra-observer reproducibility were calculated. Results: Temporal resolution significantly influenced both atrial and ventricular strain and strain rate (SR) values. Increasing temporal resolution is associated with higher absolute strain and SR values. Significant changes in strain assessment for left atrial (LA) total strain occurred between 20 and 30 frames/cycle amounting to 2,5-4,4% in absolute changes depending on spatial resolution settings. From 30 frames/cycle onward, absolute strain values remained unchanged. Significant changes of LA strain rate assessment were observed up to the highest temporal resolution of 50 frames/cycle. Effects of spatial resolution on strain assessment were smaller. For LA total strain a general trend emerged for a mild decrease in strain values obtained comparing the lowest to the highest spatial resolution at temporal resolutions of 20, 40 and 50 frames/cycle (p = 0.006-0.046) but not at 30 frames/cycle (p = 0.140). Maximum absolute changes in ventricles between lowest and highest temporal resolution were as follows: 1.8% and 0.3%/s for LV GLS and SR, 2.5% and 0.6%/s for GCS and SR as well as 1.4% for RV GLS. Changes of strain values occurred comparing 20 and 30 frames/cardiac cycle including LV and RV GLS and GCS (p < 0.001-0.046). In contrast, SR values (LV GLS/GCS SR) changed significantly comparing all successive temporal resolutions (p < 0.001-0.013). LV strain and SR reproducibility was not affected by either temporal or spatial resolution, whilst RV strain variability decreased with augmentation of temporal resolution. Conclusion: Temporal resolution affect boths atrial and ventricular strain and SR in CMR-FT deformation analyses. Spatial resolution only affects atrial functional assessment. Consistent strain assessment requires a standard spatial resolution and a temporal resolution of 30 frames/cycle, whilst SR assessment requires even higher settings of at least 50 frames/cycle.
Keywords: Cardiovascular magnetic resonance; Myocardial deformation; Atrial strain; Ventricular strain; Feature tracking; Temporal resolution; Spatial resolution; Reproducibility
 
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