Verbesserung des Gesundheitszustandes von Patienten nach aortokoronarer Bypass-Operation durch eine periinterventionelle, multimodale Behandlungsstrategie

by Sophie Charlotte Viktoria Neumann
Doctoral thesis
Date of Examination:2025-08-26
Date of issue:2025-08-01
Advisor:Prof. Dr. Thomas Meyer
Referee:Prof. Dr. Thomas Meyer
Referee:Prof. Dr. Anselm Bräuer
Sponsor:Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Persistent Address: http://dx.doi.org/10.53846/goediss-11409

 

 

Files in this item

Name:Dissertation Sophie Neumann 13_korrigiert_Fi...pdf
Size:1.45Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

Abstract Background: Coronary artery bypass grafting (CABG) is a common procedure for treating coronary artery disease but is associated with significant physical and psychological stress that can impact recovery. Psychological and environmental factors play a crucial role in postoperative outcomes and quality of life. Objective: This study evaluated the feasibility, acceptance, and efficacy of a perioperative, multimodal treatment approach aimed at improving the health status of patients undergoing elective CABG surgery. Methods: In a prospective, randomized, controlled, three-arm pilot trial (I-COPE), 88 patients were assigned to either a control group receiving standard care, an intervention group receiving psychological support (Group A), or a group receiving psychological and multimodal sensory interventions (Group B). Interventions included structured conversations, an informational booklet, light therapy, noise reduction, music therapy, and virtual reality. Outcomes included subjective health status (EQ-5D-VAS), quality of life (SF-12), pain- related disability (PDI), general self-efficacy (GSW), and serum concentrations of IL-6, IL-8, and TNF-α. Results: Both intervention groups showed improvements in psychological well-being, pain-related disability, and perceived health status. Group B demonstrated additional benefits, including reduced inflammatory markers and shorter hospital stays, indicating enhanced recovery through multimodal support. Conclusion: Perioperative multimodal interventions are feasible and well accepted. They may improve physical and psychological outcomes and support faster recovery in CABG patients. Further research is needed to validate these findings in larger cohorts.
Keywords: Coronary Artery Bypass Grafting; CABG; I-COPE; Perioperative Care; Multimodal Intervention; Psychological Support; Psychological Intervention; Pain Management; Quality of Life; Recovery Outcomes; hospital duration; Inflammatory Markers; Interleukin-6; Interleukin-8; tumor necrosis factor-α; Randomized Controlled Trial; Patient Health Status; Virtual Reality Therapy; Light Therapy; Music Therapy; Noise Reduction; Self-Efficacy; Pilot Study
 
Statistik