Wirksamkeit von kaltem Plasma auf die primäre postoperative Wundheilung nach laparoskopischer roboterassistierter radikaler Prostatektomie, eine prospektive randomisierte Studie

by Jan Lüdecke
Doctoral thesis
Date of Examination:2025-08-27
Date of issue:2025-08-18
Advisor:Prof. Dr. Lutz Trojan
Referee:Prof. Dr. Lutz Trojan
Referee:PD Dr. Moritz Thomas Schnelle
Persistent Address: http://dx.doi.org/10.53846/goediss-11435

 

 

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Abstract

English

This dissertation investigates the efficacy of cold atmospheric plasma (CAP) in promoting primary postoperative wound healing following robot-assisted laparoscopic radical prostatectomy. Given CAP’s established antimicrobial and regenerative effects in the treatment of chronic and infected wounds, the study aimed to determine whether these benefits also apply to primarily healing surgical wounds. A prospective, randomized, single-center trial was conducted at the University Medical Center Göttingen, enrolling 63 patients undergoing DaVinci-assisted prostatectomy for histologically confirmed prostate carcinoma. Each patient received both CAP-treated and non-treated (control) wounds, allowing intraindividual comparison. The plasma application was standardized, and wound healing was assessed through photographic documentation and clinical criteria. The results demonstrated no statistically significant difference in the incidence of wound healing disturbances between the CAP group (7.9%) and the control group (4.8%). Logistic regression analyses of various co-factors (age, BMI, diabetes, ASA score, tumor characteristics) revealed no significant predictors of impaired wound healing. No severe adverse effects from CAP treatment were reported. In conclusion, while CAP therapy proved to be safe and feasible, it did not yield a significant advantage over standard wound care in the context of primary healing surgical wounds. The findings suggest the need for further multicenter studies with larger sample sizes to explore potential subgroup benefits.
Keywords: cold atmospheric plasma
 
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