Light-Control of Biomimetic and Bioactive Molecules

Imse, Nils

dc.contributor.advisor	Simeth, Nadja A. Prof. Dr.
dc.contributor.author	Imse, Nils
dc.date.accessioned	2025-08-19T05:13:48Z
dc.date.issued	2025-08-19
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/16170
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11452
dc.format.extent	468	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc	540	de
dc.title	Light-Control of Biomimetic and Bioactive Molecules	de
dc.type	doctoralThesis	de
dc.contributor.referee	Steinem, Claudia Prof. Dr.
dc.date.examination	2025-07-17	de
dc.description.abstracteng	Light-controlled molecules enable precise spatial and temporal regulation of biological activity, supporting both fundamental research and the development of new therapeutics. In this work, photolipids and photocaged bioactive compounds were designed and synthesized to achieve optical control over membrane properties and biological processes. Novel fatty acids bearing different leaving groups were prepared and characterized for their photophysical and photochemical properties in solvents of varying polarity. Photolabile lipid molecules with permanent charges were also synthesized to modulate electrostatic interactions between vesicles, and their membrane behavior in vesicles was investigated, before and after irradiation. Furthermore, capsaicinoids were structurally modified to make them photodeactivatable, allowing targeted regulation of TRPV1 receptor activity. These studies demonstrate strategies for both light-induced activation and deactivation of bioactive molecules.	de
dc.contributor.thirdReferee	Tittmann, Kai Prof. Dr.
dc.contributor.thirdReferee	Walker, Johannes C. L. Prof. Dr.
dc.contributor.thirdReferee	Rhee, Jeong Seop Prof. Dr.
dc.contributor.thirdReferee	Frauendorf, Holm Dr.
dc.subject.eng	Chromoselective	de
dc.subject.eng	Photocage	de
dc.subject.eng	Membranes	de
dc.subject.eng	Lipids	de
dc.subject.eng	Bioactive Molecules	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-16170-1
dc.date.embargoed	2026-07-16
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.description.embargoed	2026-07-16	de
dc.identifier.ppn	1933644834
dc.notes.confirmationsent	Confirmation sent 2025-08-19T06:15:02	de

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