Untersuchung zu Einflussfaktoren auf das Therapieergebnis und Rezidivverhalten von operativ resezierten intrakraniellen Meningeomen

by Corinna Carla Dobroniak
Doctoral thesis
Date of Examination:2025-11-11
Date of issue:2025-11-10
Advisor:Prof. Dr. Veit Rohde
Referee:PD Dr. Steffen Unkel
Referee:PD Dr. Christoph van Riesen
Persistent Address: http://dx.doi.org/10.53846/goediss-11623

 

 

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Abstract

English

This thesis investigates the influence of different factors such as e.g. histological grade, patients' demographic data, peritumoral edema, tumor volume, surgical grade of resection and radiation on therapy outcomes and recurrence of patients with surgically resected intracranial meningiomas. Meningiomas are among the most common primary brain tumors, and despite their generally benign nature, recurrence remains a relevant clinical challenge. The study analyzes a retrospective patient cohort with a total of 141 patients treated over at least 60 months, assessing variables such as tumor location, size, histopathological grade, extent of resection, peritumoral edema, Karnofsky Performance Scale score and adjuvant treatment. Statistical models were applied to identify independent predictors of progression-free and overall survival as well as risk factors for recurrence. For evaluation of therapy outcome Karnofsky Performance Scale (KPS) was used. The results demonstrate that tumor size differs significantly in cases with recurrence during follow up. Age is also a significant factor for recurrence, wheres as the extent of resection is not. KPS Scores tended to be lower in patients with recurrence during follow up. Furthermore, the findings highlight that individualized treatment strategies, based on a combination of clinical and histopathological factors, may improve prognosis and reduce recurrence rates. The study contributes to a better understanding of the multifactorial nature of meningioma recurrence and supports the development of standarized postoperative follow-up and therapeutic strategies.
Keywords: Meningioma; recurrence; brain tumor
Schlagwörter: Meningiom; Rezidivverhalten; Karnofsky Performance Scale
 
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