Vorhof-Funktion bei Patienten mit asymptomatischer Herzinsuffizienz

Pluquet, Philip

- eine MR Studie -

dc.contributor.advisor	Sandek, Anja PD Dr.
dc.contributor.author	Pluquet, Philip
dc.date.accessioned	2025-11-12T18:07:05Z
dc.date.issued	2025-11-12
dc.identifier.uri	http://resolver.sub.uni-goettingen.de/purl?ediss-11858/16341
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-11611
dc.format.extent	42	de
dc.language.iso	deu	de
dc.subject.ddc	610	de
dc.title	Vorhof-Funktion bei Patienten mit asymptomatischer Herzinsuffizienz	de
dc.title.alternative	- eine MR Studie -	de
dc.type	doctoralThesis	de
dc.title.translated	Atrial function in patients with asymptomatic heart failure	de
dc.contributor.referee	Sandek, Anja PD Dr.
dc.date.examination	2025-11-26	de
dc.description.abstracteng	Background: Early atrial alterations in asymptomatic systolic heart failure (NYHA I) remain insufficiently defined. We aimed to quantify left- (LA) and right-atrial (RA) function using cardiovascular magnetic resonance (CMR) feature tracking (FT) and volumetry, and to assess associations with exercise capacity. Methods: In this cross-sectional substudy, 20 NYHA I patients (LVEF ≤ 40%, high exercise performance) from the TransitionCHF cohort were compared with 20 healthy controls. Phasic atrial strain parameters (εs/reservoir, εe/conduit, εa/booster) and strain rates (SRs, SRe, SRa) were derived for LA/RA, along with volumes (Vmax, Vpac, Vmin) and atrial ejection fractions; linear regression with peak VO₂/kg was performed. Results: LA εs and εe were reduced in patients (εs 30.8 ± 10.4 % vs. 44.3 ± 18.2 %, p = 0.007; εe 14.6 ± 6.9 % vs. 26.6 ± 13.1 %, p = 0.001), whereas εa was preserved (p = 0.618). LA minimal volume was higher (41.5 ± 23.4 ml vs. 26.9 ± 11.2 ml; p = 0.006), and total/booster LA ejection fractions were lower. RA strain values did not differ significantly, but RA strain rates were lower (SRs p = 0.003; SRe p = 0.003; SRa p = 0.030); RA ejection fractions showed no significant group differences. As expected, LVEF was reduced in patients (44.0 ± 5.9 % vs. 68.0 ± 6.1 %; p < 0.001). In patients, LA εe correlated with peak VO₂/kg (R² = 0.414; p = 0.004). Conclusions: Even at the asymptomatic NYHA I stage, LA reservoir and conduit functions are impaired while booster function is preserved, alongside increased LA minimal volume indicating early dilatation. The correlation between LA Conduit Strain and exercise capacity supports functional relevance and highlights atrial FT metrics as potential early markers. Confirmation in larger, prospective cohorts is warranted.	de
dc.contributor.coReferee	Unterberg-Buchwald, Christina Prof. Dr.
dc.title.alternativeTranslated	- an MRI study-	de
dc.subject.eng	Heart failure	de
dc.subject.eng	left atrium	de
dc.subject.eng	NYHA I	de
dc.subject.eng	cardiovascular magnetic resonance	de
dc.subject.eng	feature tracking	de
dc.subject.eng	atrial volume	de
dc.identifier.urn	urn:nbn:de:gbv:7-ediss-16341-1
dc.date.embargoed	2026-11-25
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Kardiologie (PPN619875755)	de
dc.description.embargoed	2026-11-25	de
dc.identifier.ppn	1941067360
dc.notes.confirmationsent	Confirmation sent 2025-11-12T19:45:01	de

Files in this item

Name:Diss-text7 .pdf

Size:1.849Mb

Format:PDF

View/Open

Name:: Diss-text7 .pdf
Size:: 1.849Mb
Format:: PDF

View/Open

This item appears in the following Collection(s)

Human- und Zahnmedizin [3399]

Show simple item record