Die Entwicklung und der Verlauf der REM-Schlaf-Verhaltensstörung bei Parkinson-Patienten

by Larissa Maria Katharina Zimansky
Doctoral thesis
Date of Examination:2025-12-15
Date of issue:2025-12-15
Advisor:Prof. Dr. Claudia Trenkwalder
Referee:Prof. Dr. Claudia Trenkwalder
Referee:Prof. Dr. Andrea Rodenbeck
Referee:PD Dr. Christoph van Riesen
Persistent Address: http://dx.doi.org/10.53846/goediss-11657

 

 

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Abstract

English

REM sleep behaviour disorder (RBD) is a parasomnia that occurs predominantly in neurodegenerative diseases such as Parkinson’s disease (PD). Moreover, in individuals with an established diagnosis of PD, RBD is associated with a more severe disease progression. However, only few studies assess the individual evolution of REM sleep without atonia (RWA) in PD patients. The 'de Novo Parkinson' study examines the longitudinal progression of RBD in a cohort of 159 de novo PD patients. RBD prevalence increased from 25% at baseline to 52% after six years. Among 31 patients with valid serial video-polysomnographies, the share of RWA increased significantly (p< 0.001) from 19% to 41% modeled to grow by 29.7% every two years. Age (p<0.04) and time (p<0.001) were identified as independent factors influencing RWA significantly. Sex, LEDD, UPDRS sum scores, benzodiazepines, MMSE total scores and dyskinesia showed no significant effect. The results support the role of RBD and RWA as progression markers in Parkinson’s disease and confirm the need for further research into its determinants and clinical implications.
Keywords: REM sleep behaviour disorder; Parkinson's disease
Schlagwörter: REM-Schlaf-Verhaltensstörung; Parkinson-Krankheit
 
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