Browsing Zentren & Graduiertenschulen by Advisor & Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 21-40 of 42
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Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
The Role of RNF40 mediated H2B monoubiquitination in transcription
(2017-02-13)Active gene transcription is tightly correlated with the occupancy of histone H2B monoubiquitination (H2Bub1) in the transcribed region. Therefore, it is has been commonly assumed that H2Bub1 is an exclusively positively ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
Analysis of the transcriptome of human NK lymphocytes
(2016-10-31)Natural Killer cells are large granular lymphocytes that contribute to both innate and adaptive immunity, as they can not only lyse infected cells or tumors, but also stimulate an adaptive immune response via production ... -
The phosphatase MKP1 as a target to enhance replicative stress and apoptosis in tumor cells
(2016-04-29)DNA replication is a tightly regulated elementary process that ensures the exact duplication and transfer of genetic information to the next generation. However, a wide range of exogenous and endogenous genotoxic insults ... -
A regulatory network of Mdm2 and members of the Polycomb Group (PcG) family
(2016-01-22)The E3 ubiquitin ligase MDM2 is the most well-known physiological antagonist of the tumor suppressor P53. P53 induces cell cycle arrest or apoptosis in the case of DNA damage, whereas MDM2 targets it for proteasomal ... -
Wif1 Inhibits the Growth of Basal Cell Carcinoma
(2015-12-22)Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin cancers and is the most commonly diagnosed cancer in fair-skinned individuals. In the majority of BCC the tumor suppressor gene patched1 (PTCH) is ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy
(2015-04-14)Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the world, and 5-Fluorouracil (5-FU) based regimens are chiefly employed for its therapy. Modern regimens, based on 5-FU in combination with ... -
Functional characterization of transketolase-like proteins and related model systems with respect to thiamin diphosphate mediated chemistry
(2014-11-12)Transketolases (TKTs, E.C 2.2.1.1) are ubiquitous distributed enzymes among all three domains of life. TKTs require thiamin diphosphate (ThDP) and bivalent cations as catalytic cofactors. They fulfill their catalytic ... -
Drug Metabolism Determines Resistance of Colorectal Cancer to Resorcinol-Based HSP90 Inhibitors
(2014-11-04)Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to ... -
Cooperation of p300 and iASPP in apoptosis and tumour suppression
(2014-11-04)Mutation or functional inactivation of tumour suppressors represents a key event in the transformation of cells and contributes to the development of cancer. P300 and CBP constitute two histone acetyltransferases with ... -
Attenuated apoptosis as consequence of Epithelial Mesenchymal Transition
(2014-08-14)The developmental program of Epithelial Mesenchymal Transition (EMT) is assumed to be involved in tumor progression, enabling cancer cells to spread from the primary tumor and form metastasis in distant tissues. At least ... -
The ubiquitin ligase G2E3 modulates cell proliferation, survival and the DNA damage response
(2014-07-28)The chemotherapeutic cisplatin is widely used to treat various tumors. By inducing crosslinking of DNA, signaling and repair pathways are activated which are referred to as the DNA damage response (DDR). However, the ... -
The Role of the Hedgehog Receptor Patched in LysM+ Cells in Mice
(2013-12-04)Cancer development is frequently linked to signaling pathways that are required for normal embryonic patterning. One of the pathways important in patterning and growth of the embryo is the Hedgehog (Hh) signaling cascade. ... -
The p53 homolog p73 takes hold of the male germ line – a novel function of TAp73 in protecting sperm cell adhesion, migration and maturation within the seminiferous epithelium of the testis
(2013-11-19)The p53 family of transcription factors possesses diverge functions in tumorigenesis and development. The evolutionarily conserved role of the family member p63 to protect the genetic stability of germ cells and influence ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ...