Browsing Zentren & Graduiertenschulen by Advisor & Referee "Ehrenreich, Hannelore Prof. Dr. Dr."
Now showing items 21-37 of 37
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Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
MicroRNA-212/132 Family is Involved in the Regulation of Long-Term Spatial Memory and Synaptic Remodeling
(2014-10-30)MicroRNAs are noncoding transcripts with crucial functions in probably every organ system. The roles of miRNAs in neuronal processes and cognitive functions are recently being appreciated. The discovery of neuronal activity ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ... -
Modeling neuropsychiatric phenotypes in mice in the frame of translational neuroscience
(2014-01-20)Neuropsychiatric disorders, such as autism spectrum disorders (ASD), schizophrenia, anxiety disorders, major depression and substance use disorders are highly prevalent and contribute to disease burden worldwide. Accumulating ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
The influence of common genetic variations in candidate genes on neuropsychiatric phenotypes
(2013-08-09)Introduction: Psychiatric disorders are ‘complex diseases’. A large proportion of the phenotypic variation of psychiatric conditions like schizophrenia and autism can be attributed to additive genetic effects (80%-90%). ... -
Neuronal pathology in targeted cortical experimental autoimmune encephalomyelitis and multiple sclerosis
(2013-07-09)In the recent years it has become increasingly obvious that multiple sclerosis (MS) is not only a white matter (WM) disease of the central nervous system (CNS) but also involves frequently and extensively the grey matter ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
(2011-05-02)Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate gene ... -
Studies on the Involvement of the Immune system in Alzheimer's disease
(2010-08-12)The main subject of this doctoral work is the role of the immune system in Alzheimer's disease (AD), and how its understanding may help to develop novel diagnostic and therapeutic options ... -
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
Pathological Alterations Induced by intraneuronal in Alzheimer’s Disease
(2010-01-18)Alzheimer’s disease (AD) is pathologically characterized by the deposition of amyloid beta (Aβ) and neurofibrillary tangles (NFT) consisting of hyperphosphorylated tau protein. Since familial mutations in proteins ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ...