Browsing Zentren & Graduiertenschulen by Advisor & Referee "Fischer, André Prof. Dr."
Now showing items 21-40 of 45
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The role of alpha-synuclein on transcriptional deregulation in Parkinson’s disease
(2018-08-31)Parkinson’s disease (PD) is a complex neurodegenerative disorder that manifests through a broad ran ge of motor and non - motor symptoms. Alpha - synuclein (aSyn) is the major ... -
Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
(2018-07-12)Histone ubiquitylation is the post-translational covalent attachment of ubiquitin to histones. Ubiquitylation of histones regulates chromatin-templated processes through a combination of structural and functional effects. ... -
BAF155 regulates the genesis of basal progenitors through both Pax6-dependent and independent mechanisms during cerebral cortex development
(2018-04-10)During mammalian development, the balance between symmetric and asymmetric division of radial glial (RG) progenitors regulates the tangential size versus radial growth of the cerebral cortex. The pool of basal progenitors ... -
Dlk1 Membrane-to-Nuclear Signalling During Motor Neuron Functional Diversification
(2017-11-20)Motor neurons of the spinal cord and hindbrain are responsible for translating neural commands into movements. For the execution of smooth movements, it is necessary that motor neuronal impulses are in turn translated into ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
miRNAs in protection and regeneration of dopaminergic midbrain neurons
(2017-02-24)PD is the second most frequent neurodegenerative disorder affecting over 3 % of the population older than 80 years of age. Although PD is a system disorder which affects most regions of the brain, the progressive demise ... -
Neuronal correlates of implicit learning in the mammalian midbrain
(2016-08-29)Filtering auditory information according to its relevance is critical to elicit the appropriate behavioral response. The relevance of a sound is not carried by the sound itself but rather assigned by the brain based on ... -
Epigenetic Modulation in Alzheimer's Disease: Function of Hippocampal microRNAs
(2015-12-04)MicroRNAs (miRNA) are small non-coding RNAs that play a critical role in the regulation of gene expression programs and thus key mediators of cellular homeostasis. There is increasing evidence that deregulation of miRNAs ... -
The Role of Lysine Acetyltransferase Tip60 in the Murine Hippocampus
(2015-07-07)Making new memories is a highly complex process, which involves rapid modifications of existing proteins, induction of gene expression, de novo protein synthesis, and the altering of neuronal structures. The cellular ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain
(2015-04-20)From early neurogenesis to the maintenance of post-mitotic neurons, apoptosis plays a pivotal role. Uncontrolled apoptotic events can lead to abnormal neuronal cell loss, which is a hallmark of various neurodegenerative ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Transcriptional control of the establishment of neocortical projections in the mammalian telencephalon
(2015-01-12)Neuronal connections in the neocortex that relay and integrate informationform the basis of our higher cognitive abilities. Transcription factors play animportant role in controlling the trajectory of neuronal projections. ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
Coding and Non-Coding RNA in Age-Associated Memory Impairment and Alzheimer's Disease
(2014-06-03)The phenomenon of population aging, caused by increased life expectancy and declining birth rates, has resulted in a high, and continuously rising proportion of elderly people in the population. This means it is critical ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Mechanistic insights into alpha-Synuclein neuronal toxicity: misfolding, serine phosphorylation and interactions with Rab GTPases
(2013-11-18)Alpha-Synuclein(aS), a protein abundant in presynaptic neurons, has been found as the major component of Lewy bodies, the neuronal inclusion identified as the hallmark of Parkinson’s disease (PD). aS adopts intrinsically ... -
The role of Kat2a during memory formation and chromatin plasticity in the aging murine hippocampus
(2013-07-18)Evolution has equipped multicellular organisms with ever more sophisticated means of processing information about the environment they live in. The hippocampus has been shown to be one of the most important structures of ...