Browse by type "cumulativeThesis"
Now showing items 21-40 of 118
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Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ... -
Lipids in plant development and stress responses
(2023-08-22)In plant cells, lipids are important components of cellular membranes. There, they act as structure-forming and/or signal-transmitting elements. As signals, lipids are landmarks and thereby important regulators, for example ... -
The evolution of hydrophobic barriers among land plants
(2023-08-03)The terrestrialization of plants required major physiological and metabolic adaptations, including the capacity to deposit extracellular hydrophobic barriers that shield plant surfaces against various abiotic and biotic ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Integrational modelling for molecular analysis in a CRISPR/Cas edited iPSC-cardiomyocyte model of Dilated Cardiomyopathy
(2023-07-05)Machine learning has shown promising results in the prediction and diagnosis of cardiac diseases. By analyzing large amounts of patient data, such as imaging, genomics, or molecular phenotyping data, machine learning ... -
Coordination of the cell cycle and the cytoskeleton during oocyte meiosis
(2023-06-29)Meiosis serves to reduce ploidy, to half the genetic content of germ cells before they unite again at fertilization. This is achieved by two subsequent divisions called meiosis I and II without an intermittent S-phase. In ... -
Collembola communities across forest ecosystems in Germany: Long-term dynamics and interrelationships with fungal food resources
(2023-06-20)Collembola, one of the most abundant animals in soils worldwide, are important drivers of soil ecosystem services such as carbon sequestration and the cycling of organic matter. By feeding on fungal hyphae and spores, they ... -
Nemoral European Beech and Oak Forests under Climate Change
(2023-05-16)Global warming and increasing drought severity are exposing temperate forests to higher stress levels, challenging forest management in the 21st century. With a projected warming by 2–3 K until 2070, silvicultural adaptation ... -
Neural circuit plasticity underlying learning and memory in Drosophila melanogaster: from synaptic connections to behavior
(2023-05-12)Understanding the principles behind olfactory higher-order associative chains formation in Drosophila is one step further into unraveling the essence of learning and memory. However, the rationale behind such mechanisms ... -
Characterizing intracellular lipid signaling in dilated cardiomyopathy using human iPSC-derived cardiac cells
(2023-04-18)Sarcomere protein misalignment is a primary consequence of inherited mutations causing dilated cardiomyopathy (DCM) and results in severe molecular patho-phenotypes in cardiomyocytes from patients. In this study, human ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Modulation of sensory processing under different modes of reward cueing
(2023-04-13)Rewards not only shape our value-based choices but also affect our simple perceptual decisions. Accordingly, behavioral and neural correlates of reward-driven effects on perception have already been identified at the ... -
The Verticillium dahliae Vta3 genetic network and hydrophobins are required in tomato xylem sap for plant disease
(2023-03-27)The ascomycete Verticillium dahliae is a pathogenic fungus for a variety of important crops and spends long phases of its life cycle in the vascular xylem system of particular host plants. Growth in this unique and ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Metabolism of NHP and SA
(2023-01-02)When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ... -
Functional and Structural Characterization of the DEAH-box Helicase Prp43
(2022-11-24)RNA helicases of the DEAH-box family fulfill essential functions in various aspects of RNA metabolism by reorganizing structured RNAs and RNPs through ATP-dependent motility in 3’ to 5’ direction along single-strands. Prp43 ... -
Cystic Fibrosis as a model use case for implementing cell based disease models in systems medicine
(2022-11-22)In the last two decades, tremendous progress has been made in producing large amounts of biological and biomedical data in a time- and cost-effective manner. Along with the increasing amount of data has come the requirement ... -
Actin promotes chromosome aggregation and accurate chromosome segregation in mammalian oocytes
(2022-09-15)Accurate chromosome segregation during meiosis is essential for the formation of a new life. During meiosis, spindle microtubules bind to the chromosomes’ kinetochores and arms in order to separate the genetic material. ... -
The Dynamic Organization of Proteins in the Synaptic Bouton
(2022-09-12)Protein availability is crucial for maintaining cellular processes. In synapses, the identities and functions of proteins involved in neurotransmission are well known. Their spatial distribution, copy numbers, and lifetimes ...