Browsing Zentren & Graduiertenschulen by Advisor & Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 41-46 of 46
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The p53 homolog p73 takes hold of the male germ line – a novel function of TAp73 in protecting sperm cell adhesion, migration and maturation within the seminiferous epithelium of the testis
(2013-11-19)The p53 family of transcription factors possesses diverge functions in tumorigenesis and development. The evolutionarily conserved role of the family member p63 to protect the genetic stability of germ cells and influence ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction
(2009-12-15)P53 is at the center of the control systems that mediate the response to DNA damage, leading to cell cycle arrest or apoptosis. Virus infection can cause a DNA damage response through virus ...