Browsing Zentren & Graduiertenschulen by Advisor & Referee "Fischer, André Prof. Dr."
Now showing items 1-20 of 45
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The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies
(2025-01-23)Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ... -
Generation of innervated engineered human myocardium (iEHM) from human induced pluripotent stem cells to elucidate the mechanism underlying neuro-cardiac pathologies
(2024-11-12)Brain and heart consist of networks of excitable cells, the function of which is orchestrated by a complex interplay of ionic currents. Mutations in ion channels can predispose patients to cardiocerebral channelopathies ... -
A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
Recycling as a mechanism for extracellular matrix remodeling at the synapse
(2021-12-10)In the adult brain, the extracellular matrix (ECM) forms lattices that sheath neurons and synapses. The exceptional longevity of ECM molecules lends these lattices a unique durability, and as such, they are deemed to ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
A cortical hierarchy for differential GABAergic circuit motifs as targets for stress-induced alterations in endocannabinoid signaling
(2021-09-17)Aberrant endocannabinoid (eCB) signaling has been implicated in the pathophysiology of different stress-related psychiatric diseases, such as schizophrenia, depression, and anxiety disorders. Such eCB signaling is triggered ... -
Cocaine-induced synaptic changes in the nucleus accumbens: role in drug-motivated behaviour and relapse risk
(2021-05-17)Chronic drug use creates robust and durable memories which, even after years of abstinence, can be reawakened by drug-associated cues and trigger craving and relapse. Addictive drugs elevate extracellular dopamine levels ... -
The Synaptic RNAome - identification, interactions and intercellular transfer
(2021-03-19)Synaptic plasticity is how neurons adapt to new stimuli and necessitates changes in synaptic weight. For these changes to be durable, local translation in neurites, and at pre- and post-synapses is required. Current methods ... -
Investigation of brain networks for personalized rTMS in healthy subjects and patients with major depressive disorder: A translational study
(2021-02-19)Depression is a complex psychiatric disorder with emotional dysregulation at its core. The first line of treatment includes cognitive behaviour therapy and pharmacological antidepressants. However, up to one third of ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Role of prion protein in synucleinopathies
(2020-06-11)Synucleinopathies comprise a group of neurodegenerative diseases, characterized by deposits of aggregated alpha-synuclein (aSyn) in neurons and glia. The special hallmark is the presence of Lewy bodies and Lewy neuritis, ... -
Multi-omics analysis of human brain tissue and an animal model of Parkinson’s Disease
(2020-01-24)Parkinson’s Disease (PD) is the second most prevalent and fastest-growing neurological disorder. The number of affected individuals is expected to double in the next 20 years. The exact molecular mechanisms underlying PD ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ...