Browsing Zentren & Graduiertenschulen by Advisor & Referee "Rehfeldt, Florian Dr."
Now showing items 1-13 of 13
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Constitutive Modeling for Tissue Engineered Heart Repair
(2020-10-27)Computer-aided therapy design is an intricate endeavor intertwining all scales from molecules to cells and tissues to organs. Changing one such component in a living system can have far-reaching effects, diffcult to ... -
Molecular DNA Sensors to Measure Distribution of Cytoskeletal Forces
(2020-08-24)Actin, a major cytoskeletal biopolymer in eukaryotic cells, is crosslinked into networks of filaments and bundles. These networks are largely responsible for the maintenance of cellular shape, rigidity, and mechanical ... -
Flows, morphology, and memory: study of a living network
(2020-06-22)The complex behaviour of the slime mould Physarum polycephalum, a simple eukaryote, has been puzzling researchers since its discovery. The giant unicellular, but multinucleate organism is highly successful at tackling ... -
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Structure and Mechanics of Neuronal Model Systems
(2019-11-15)Neurons of advanced animals need fast and efficient mechanisms to enable the functionality of a complex nervous system. In the life cycle of synaptic vesicles this is reflected in the endocytosis which generates new vesicles, ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Investigation of membrane fusion as a function of lateral membrane tension
(2017-09-21)Membrane fusion in native systems occurs on very short time scales and it has been proposed that lateral membrane tension of the presynaptic membrane is substantially increased to facilitate fusion. Proteins of the SNARE ... -
Fluorescence correlation spectroscopy for studying intermediate filament assembly
(2017-08-10)Intermediate filaments play a central role in the cytoskeleton of eukaryotic cells. Together with microtubules and actin filaments they determine the mechanical properties of cells. Microtubules are also the guiding tracks ... -
Acto-myosin based mechano-sensitivity of cells - comparing human mesenchymal stem cells and differentiated cells
(2017-08-09)Within the last decades it was discovered that the cellular microenvironment plays an important role in cellular processes and cell fate can be directed by mechanical properties of the extracellular matrix (ECM), which can ... -
Structure and dynamics of stress fibers in adult stem cells
(2016-07-19)Since decades, the differentiation potential of adult human mesenchymal stem cells (hMSCs) is investigated. They feature the ability for differentiation into various cell types, like cartilage, fat, nerve, muscle and ... -
Mechanics of suspended cells probed by dual optical traps in a confocal microscope
(2015-12-02)Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. In this thesis, we quantitatively measured forces and elastic spring constants of ... -
Blood Platelet Behavior on Structured Substrates
(2015-11-02)Blood clotting is the immediate answer of the body to injuries. In this process, blood platelets adhere to the injured site, spread over the wound and form a blood clot, in which single platelets are connected by fibrin ...