Browsing Zentren & Graduiertenschulen by Advisor & Referee "Richter-Dennerlein, Ricarda Dr."
Now showing items 1-10 of 10
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Rate-limiting steps of autophagy initiation
(2024-12-23)Autophagy research has progressed tremendously since the identification of ‘ATG’ genes and proteins responsible for maintaining the process. A dissection of general functions of all proteins involved was possible. However, ... -
Investigation of the dual role of mL62 during the mitoribosome assembly and rescue
(2024-12-19)Mitochondria are eukaryotic organelles, which have their own DNA (mtDNA) that encode for 13 proteins that are essential for the oxidative phosphorylation. The mitochondrial ribosome (mitoribosome) is responsible for the ... -
Interplay of proteins and lipids during endoplasmic reticulum-associated protein degradation
(2024-11-14)The endoplasmic reticulum controls lipid homeostasis due to its central role in lipid biosynthesis and its regulation. Aberrant lipid composition and membrane properties in the endoplasmic reticulum interfere with its ... -
Functional characterisation of DHX proteins in the regulation of RNA metabolism and genome stability
(2023-08-08)Cells contain a multitude of different RNAs, which are highly versatile biomolecules that have crucial functions in almost all cellular processes. Furthermore, the inter-relationship between RNA and proteins is essential, ... -
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a
(2022-12-09)Translation termination is the last step of ribosomal protein synthesis. Dedicated translation factors are imported into mitochondria to convert the information stored in the retained mitochondrial DNA (mtDNA) and to ... -
The role of GTPases in human mitochondrial ribosome biogenesis
(2022-05-03)Mitochondria are essential organelles of eukaryotic cells, which produce the vast majority of the cellular ATP via oxidative phosphorylation (OXPHOS). The mitochondrial gene expression machinery contributes to the formation ... -
Molecular insights into the roles of RNA helicases during large ribosomal subunit assembly
(2021-02-25)RNA helicases are enzymes present in all domains of life that are important in many aspects of RNA metabolism. They harbor a conserved helicase core that uses the energy of NTP binding and hydrolysis to change affinity to ... -
Insights into the biogenesis of the human mitochondrial ribosomal large subunit – Characterisation of mL44 and mL45
(2020-11-16)Due to the presence of high-resolution cryo-EM structures of the human mitoribosome, the understanding about the function and assembly of the intriguing mitochondrial ribonucleoprotein complex increased tremendously during ... -
Analysis of the Interactome and Membrane Insertion of VAPB, a Tail- Anchored Protein at the Inner Nuclear Membrane
(2020-06-26)Tail-anchored (TA) proteins are a group of integral membrane proteins defined by the presence of a single transmembrane domain (TMD) at the C-terminal domain and are involved in functionally diverse cellular processes. ...