Browsing Zentren & Graduiertenschulen by Advisor & Referee "Saher, Gesine Dr."
Now showing items 1-3 of 3
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Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Differential metabolic alterations in cortical cell types by feeding a ketogenic diet
(2020-06-18)The suckling period of rodents is accompanied by marked ketosis as a result of the high fat content of maternal milk. During this time, ketone bodies are the major source of energy for the brain. After weaning when the ... -
Genetic manipulation of CNS cholesterol metabolism and its effects on cerebral β-amyloidosis
(2019-03-07)Accumulating evidence implicates cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD). However, the underlying mechanisms are not well understood. In the brain, cholesterol is synthesized locally by ...