Browsing Zentren & Graduiertenschulen by Referee "Pöhlmann, Stefan Prof. Dr."
Now showing items 1-8 of 8
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The role of Sec61β in Ebola and Marburg virus glycoprotein processing and the potential of the Sec61 channel as antiviral target
(2025-11-10)Ebola virus (EBOV) and Marburg virus (MARV), members of the family of Filoviridae, are highly pathogenic for humans and non-human primates (NHPs) and lead to reoccurring outbreaks mainly in the region of West, East and ... -
Immortalized Primate Granulosa Cell Lines and Pluripotent Stem Cell-Derived Early Germ Cells: Towards Ovarian Follicles In Vitro
(2025-10-24)Access to primate ovarian tissue and mature oocytes is extremely limited, yet these resources are crucial for advancing both infertility treatment and fundamental research in reproductive biology. Conventional sources are ... -
Targeting SARS-CoV-2 with Nanobodies and Antibodies: Neutralization and Escape Variants
(2025-05-15)The SARS-CoV-2 pandemic revealed significant limitations in existing preventive measures against coronavirus infections. Before vaccines were approved, over 64 million infections and 1.6 million deaths were reported ... -
Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Identification of factors involved in cell wall homeostasis and tolerance towards quaternary ammonium compounds in Listeria monocytogenes by genomic adaptation
(2023-06-20)Listeria monocytogenes is one of the most successful food-borne pathogens worldwide. Despite available treatment with cell wall targeting antibiotics an infection with concomitant development of listeriosis results in death ... -
Cell and Receptor Tropism of γ2-Herpesviruses
(2021-02-25)Kaposi’s sarcoma-associated herpesvirus (KSHV), the only rhadino- or γ2-herpesvirus of humans, is associated with Kaposi’s sarcoma (KS) and two B cell proliferative malignancies, primary effusion lymphoma (PEL) and a ... -
Novel production system for influenza A virus-derived defective interfering particles and analysis of antiviral activity
(2020-09-24)Influenza A virus (IAV) increases morbidity and mortality rates and novel antivirals are needed to combat the virus. Errors of the viral polymerase lead to the generation of defective RNAs. These DI-RNAs may interfere with ... -
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
(2020-07-24)Human coronaviruses (HCoV) mainly cause common cold-like symptoms. However, in the last two decades the emerging coronaviruses the severe acute respiratory syndrome coronavirus (SARS-CoV) (in 2002), Middle East respiratory ...